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Acetylcholine receptor autoantibodies have been found in subsets of #MECFS and #POTS patients. This can impair autonomic nervous system function and mast cell regulation. What I did not know is that these autoantibodies can also impair collagen synthesis.
Acetylcholine autoantibodies in #MECFS and #POTS: https://me-pedia.org/wiki/Acetylcholine#Chronic_fatigue_syndrome
Herpesviruses and acetylcholine autoantibodies: https://me-pedia.org/wiki/Acetylcholine#Myasthenia_Gravis
Collagen synthesis in acetylcholine receptor M3 KO mice: https://www.sciencedirect.com/science/article/abs/pii/S0024320512003864
Is it possible that a subset of patients have an acquired, autoimmune connective tissue disorder? Could this help explain observations of: herpesvirus reactivation, dysautonomia, MCAS, and elevated hydroxyproline/lysine in a subset of #MECFS patients, w/ w/o hypermobility?
“Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts” https://erj.ersjournals.com/content/32/3/555.short
Maybe we should all start smoking!*
“Nicotine promotes proliferation and collagen synthesis of chondrocytes isolated from normal human and osteoarthritis patients” https://link.springer.com/article/10.1007/s11010-011-1020-1
*very much kidding
“Nicotine promotes proliferation and collagen synthesis of chondrocytes isolated from normal human and osteoarthritis patients” https://link.springer.com/article/10.1007/s11010-011-1020-1*very much kidding
**sorry—I should have said MAY impair collagen synthesis, since acetylcholine receptors play an important role in collagen synthesis, and autoimmunity to these receptors can impair their function, and thus the action of acetylcholine on the cells.
