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Acetylcholine receptor autoantibodies have been found in subsets of #MECFS and #POTS patients. This can impair autonomic nervous system function and mast cell regulation. What I did not know is that these autoantibodies can also impair collagen synthesis.
https://abs.twimg.com/emoji/v2/... draggable="false" alt="🤯" title="Explodierender Kopf" aria-label="Emoji: Explodierender Kopf">
Is it possible that a subset of patients have an acquired, autoimmune connective tissue disorder? Could this help explain observations of: herpesvirus reactivation, dysautonomia, MCAS, and elevated hydroxyproline/lysine in a subset of #MECFS patients, w/ w/o hypermobility?
Maybe we should all start smoking!*https://abs.twimg.com/emoji/v2/... draggable="false" alt="5️⃣" title="Tastenkappe Ziffer 5" aria-label="Emoji: Tastenkappe Ziffer 5"> “Nicotine promotes proliferation and collagen synthesis of chondrocytes isolated from normal human and osteoarthritis patients” https://link.springer.com/article/10.1007/s11010-011-1020-1
*very">https://link.springer.com/article/1... much kidding
*very">https://link.springer.com/article/1... much kidding
**sorry—I should have said MAY impair collagen synthesis, since acetylcholine receptors play an important role in collagen synthesis, and autoimmunity to these receptors can impair their function, and thus the action of acetylcholine on the cells.
