It has been an incredible month for new research about MPNs and MPN-AP/BP! Here are some articles that caught my eye (by no means a comprehensive list!) #mpnsm #leusm

A large-scale GWAS identifying 17 MPN risk loci and suggesting MPN risk is associ w/ function & self-renewal of hematopoietic stem cells

https://www.nature.com/articles/s41586-020-2786-7

Pre-clinical work in a murine MPN model demonstrating the potentiation of interferon-alpha with arsenic trioxide

https://rupress.org/jem/article/218/2/e20201268/211476/JAK2V617F-myeloproliferative-neoplasm-eradication

Analysis of PV and ET patients identifying pathogenic mutations associated w/ early, intermediate, and late patterns of progression to AML

https://ashpublications.org/bloodadvances/article/4/19/4887/464197/Leukemic-evolution-of-polycythemia-vera-and

Retrospective analysis of MPN-BP patients undergoing transplant compared to de-novo AML and AML arising from MDS

https://ashpublications.org/bloodadvances/article/4/19/4748/463999/Comparison-of-outcomes-of-HCT-in-blast-phase-of

And results from a Phase II study of Rux + decitabine in MPN-AP/BP patients

https://ashpublications.org/bloodadvances/article/4/20/5246/469734/Phase-2-study-of-ruxolitinib-and-decitabine-in#.X5eDhhmpZK4.twitter