This is your regular reminder that unfollowing, muting and blocking are all options. Curate your timeline to protect your mental health. Your wellbeing, your attention, your time and your energy is precious.

You can also adjust your settings to remove unwanted contacts. Go to settings, filters and muted notifications and tick the boxes:
replies from people who don't follow you
who have a new account
who have a default photo
who haven't confirmed their email and phone number

I'd also suggest keeping your DMs shut. People can ask for your contact details or you can have them included in another link via your profile. And you can also mute words, hashtags and people's names.

All the above should keep out a lot of unpleasantness but if you encounter abusive accounts (either targeting you or you witness targeting someone else) Twitter Block Chain can take out abusers and their followers. You can always unblock non-abusive followers caught in the trap

Btw the steps above don't stop you being able to read or interact with others unless they have muted or blocked you. So you can reply to people you don't follow, who don't follow you or have accounts set up without photos, email/phone etc. That's interaction on your terms.

Obviously, while you're doing all you can to screen out abusers, do all you can to be the kind of person that isn't screened out yourself. Either in the way you interact, or by sorting your account so you aren't accidentally screened out.

You don't have to tell other people who you've unfollowed, muted or blocked. It might be safer for you to keep this quiet or reduce drama. Although you may want to alert others if you've needed to do this so they can stay safe.

You don't have to explain your choices unless you want to. And if someone you have blocked on one platform turns up being difficult on another, block there too (including diverting their email to spam).

On a much more positive note, do check who you've followed as often Twitter unfollows for you. You want to keep in touch with those you like and learn from. Seek new people to interact with too. And tell those whose tweets you appreciate that they are noticed and cared about.