1/3 Interesting data from @guptalabunc lab on cellular radioresistance mediated by TP53 which accelerates DNA-PK dependent DSB repair.
#ASTRO20
#radbio
#ASTRO20
#radbio
2/3 @guptalabunc reporting elegant cell based analyses to understand p53 dependent DSB repair kinetics and identify backup repair pathways in p53 deficient cells.
p53 and radioresistance is complicated eg
https://pubmed.ncbi.nlm.nih.gov/15197326/
https://pubmed.ncbi.nlm.nih.gov/15688024/
#ASTRO20
#radbio
p53 and radioresistance is complicated eg
https://pubmed.ncbi.nlm.nih.gov/15197326/
https://pubmed.ncbi.nlm.nih.gov/15688024/
#ASTRO20
#radbio
3/3 I am curious if TP53 will pan out as predictor of radioresistance in the clinic. Complicated protein, not all mutations are equal & by itself it may have more prognostic rather than predictive value in patients treated with #radiotherapy
Wonder what others think?
#ASTRO20
Wonder what others think?
#ASTRO20
I need that Twitter edit function, or less distractions
This is meant to read that TP53 loss accelerates DSB repair !!
sorry @guptalabunc

This is meant to read that TP53 loss accelerates DSB repair !!
sorry @guptalabunc