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Role of Zinc (Zn) during #COVID19: Probably The 2nd most important nutrient after #VitaminD. Zn is a must with antivirals in standard COVID care.
1. A study from Spain with 249 pts reported a zinc deficiency increased the risk of death by 2.3 times.
https://medicalxpress.com/news/2020-09-zinc-blood-death-patients-covid-.html
1. A study from Spain with 249 pts reported a zinc deficiency increased the risk of death by 2.3 times.
https://medicalxpress.com/news/2020-09-zinc-blood-death-patients-covid-.html
2. A study from Japan reported Zn deficiency in 14% pts who remained mild to moderate & 84% among them later progressed into severe COVID 19. https://www.ijidonline.com/article/S1201-9712(20)30723-2/fulltext#%20
3. A study from India with 47 COVID 19 pts & 45 healthy controls revealed that the COVID 19 pts had significantly lower Zn level & developed more complications (70.4% Vs. 30.0%, p=0.009). Zn def. pts also had a prolonged hospital stay. (7.9 d Vs 5.7 d). https://www.ijidonline.com/article/S1201-9712(20)30730-X/fulltext
4. A study involving 962 pts reported a 44% reduction in death among 441 patients who received #hydroxycholoroquine, Azithromycin & Zn than 521 pts who received just HCQ and Az.
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001250
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001250
5. Zn as a Virus blocker: Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176
6. The most common symptoms of COVID-19 are impaired smell & taste, fever, cough, sore throat, general weakness, pain as aching limbs, runny nose, and in some cases diarrhea. All these symptoms are associated with altered zinc homeostasis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078827/
7. An ex-vivo model of chronic obstructive pulmonary disease (COPD) showed that decreasing zinc levels raised the leakage of the epithelium of the respiratory tract.
https://pubmed.ncbi.nlm.nih.gov/29255357/
https://pubmed.ncbi.nlm.nih.gov/29255357/
8. A review article titles "Zinc as a Gatekeeper of Immune Function" discusses underlying mechanisms responsible for the regulation of cellular signaling by alterations in zinc homeostasis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748737/
9. Zinc deficiency in an experimental human model caused an imbalance between Th1 and Th2 functions.
https://academic.oup.com/jid/article/182/Supplement_1/S62/2191506
https://academic.oup.com/jid/article/182/Supplement_1/S62/2191506
10. The World Health Organization (WHO) in 2002 assumes that at least one-third of the world population is affected by zinc deficiency. The fact that zinc deficiency is responsible for 16% of all deep respiratory infections worldwide. https://pubmed.ncbi.nlm.nih.gov/12691085/
11. A recent review ranked zinc as the top three most vital nutrients for immunological health, alongside vitamins C and D. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019735/
12. Broad Functions of Zinc:
- Immune cells’ activities
- Production of antibodies
- Recruitment of immune cells to the infection site
- Reduction of inflammation and oxidative stress
- Maintenance of the integrity of the organs
Key: Zn + Antiviral + Vitamin C + Vitamin D
- Immune cells’ activities
- Production of antibodies
- Recruitment of immune cells to the infection site
- Reduction of inflammation and oxidative stress
- Maintenance of the integrity of the organs
Key: Zn + Antiviral + Vitamin C + Vitamin D
@KundanDSolanki @rebelhealth1 @mumbaimatterz @MNCDFbombay @PeterVermont @chitguppi this thread to look at.
