"Sleep Disorders - Circadian Rhythms for the Chest Clinician: It's About Time" starting in less than 5 minutes! Join NOW! #CHEST2020 #CHESTSoMe @accpchest

@PhyllisZee: Way beyond sleep-wake disorders! #CHEST2020 #CHESTSoMe @accpchest

How fast is your cellular clock ticking? Genetic components of the Mamalian Systems
@PhyllisZee #CHEST2020 #CHESTSoMe @accpchest

Circadian Dysfunction is also related to Internal synchronization cycles between all our various organ systems! @PhyllisZee #CHEST2020 #CHESTSoMe @accpchest

What do you think??
@PhyllisZee #CHEST2020 #CHESTSoMe @accpchest

And the answer is .................................... watch the video! Or join us live right now!!
@PhyllisZee #CHEST2020 #CHESTSoMe @accpchest

How can we manipulate the circadian rhythm?
@PhyllisZee #CHEST2020 #CHESTSoMe @accpchest

Broad implications of Circadian Disturbance!
@PhyllisZee #CHEST2020 #CHESTSoMe @accpchest

"Drug the clock and Clock the Drug" - @PhyllisZee

Learn the link between Circadian Rhythms and Asthma/COPD - @g_mak #CHEST2020 #CHESTSoMe @accpchest

Nocturnal Asthma - some things have been known since the 5th century!
@g_mak #CHEST2020 #CHESTSoMe @accpchest

Are clock genes linked to Asthma?
@g_mak #CHEST2020 #CHESTSoMe @accpchest

Are clock genes linked to COPD then?
@g_mak #CHEST2020 #CHESTSoMe @accpchest

Single dose of steroids is effective!
@g_mak #CHEST2020 #CHESTSoMe @accpchest

Similar studies have been conducted in bacterial PNA, viral PNA and now there are newer studies starting in COVID-19!
@g_mak #CHEST2020 #CHESTSoMe @accpchest

@PisaniMAP on Circadian Rhythms in Critical Care!
#CHEST2020 #CHESTSoMe @accpchest

Interplay in Sleep Disruption, Delirium and Circadian Rhythm!
@PisaniMAP #CHEST2020 #CHESTSoMe @accpchest

Activity was lower in Critically Ill Patients - @PisaniMAP #CHEST2020 #CHESTSoMe @accpchest

Light, meals, social cues, exercise, ... can all impact Circadian rhythm in the ICU
@PisaniMAP #CHEST2020 #CHESTSoMe @accpchest

Mind-blowing: Melatonin secretions are rapidly disrupted within one day of ICU stay!!
@PisaniMAP #CHEST2020 #CHESTSoMe @accpchest

Delirium associated with disruption in melatonin secretion! @PisaniMAP #CHEST2020 #CHESTSoMe @accpchest

@DiwakarB1988 on Circadian Rhythms and Cancer!
#CHEST2020 #CHESTSoMe @accpchest

"Shift work is carcinogenic"
@DiwakarB1988 #CHEST2020 #CHESTSoMe @accpchest

@DiwakarB1988 #CHEST2020 #CHESTSoMe @accpchest

There are multiple mechanisms linking the disruption of circadian rhythm and tumor growth
@DiwakarB1988 #CHEST2020 #CHESTSoMe @accpchest

What can we do about it?
- Chronotherapy
- Target clock genes
- And more!

@DiwakarB1988 #CHEST2020 #CHESTSoMe @accpchest

Chronorehabilitation can help restore Circadian Rhythm
@DiwakarB1988 #CHEST2020 #CHESTSoMe @accpchest

Melatonin dosing:
Low dose: 0.5mg
Right time: Early evening, NOT at bedtime

Thank you to all the presenters: @PhyllisZee @g_mak @PisaniMAP @DiwakarB1988
Thank you to moderator @gretchemaben
This was an extremely informative for me! Thank you #CHEST2020 #CHESTSoMe @accpchest