In Clinglio we are testing the efficacy of a novel treatment for #glioblastoma: 2OHOA. Want to know how it works? Follow the thread!

2OHOA is a synthetic derivative of oleic acid that has an important advantage: it can reach tumor cells in the brain by crossing the blood-brain barrier This layer of cells blocks the access of many other #glioblastoma drugs.

2OHOA acts by activating a key enzyme (sphingomyelin synthase 1, or SMS1) that regulates the membrane cell composition

In #glioblastoma, the lipid composition of the membrane of cancer cells is altered. This increases the amount of key signaling proteins embedded in the membrane, which promote the advance of the disease.

2OHOA indirectly dislodges signaling proteins like K-Ras, that are involved in pathways that produce cell proliferation. This stops their activity and thus, reduces the tumor growth.

If you want to know more about this innovative treatment, visit our website! http://clinglio.eu