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@farid__jalali @__ice9 Melatonin seem to help as well. https://www.medrxiv.org/content/10.1101/2020.10.15.20213546v1">https://www.medrxiv.org/content/1...
"Melatonin inhibits several physiological processes in platelets including the aggregation phenomenon the release of ATP and serotonin"
https://europepmc.org/article/med/7865868">https://europepmc.org/article/m...
https://europepmc.org/article/med/7865868">https://europepmc.org/article/m...
https://pubmed.ncbi.nlm.nih.gov/19963060/ ">https://pubmed.ncbi.nlm.nih.gov/19963060/...
We report that both resting and stimulated mast cells synthesize and release melatonin. We also report that the necessary machinery to synthesize melatonin is present in mast cells
https://www.tandfonline.com/doi/full/10.1080/15287394.2019.1615019">https://www.tandfonline.com/doi/full/...
MEL significantly inhibited LPS-mediated upregulation of COX-2 in microglia. ELISA demonstrated that prostaglandin E2 (PGE2), the downstream effector of COX-2, concentrations were also reduced. In addition, MEL was found to decrease activation of ERK1/2, JNK, p38 MAPK, and NF-κB.
"Exposure of platelet-rich plasma samples to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated the melatonin effect on the kinetic parameters of platelet 5HT uptake." https://pubmed.ncbi.nlm.nih.gov/8366770/ ">https://pubmed.ncbi.nlm.nih.gov/8366770/&...
"Melatonin inhibits SERT mediated 5‐HT uptake in human and mouse derived platelets and synaptosomes" https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.26.1_supplement.lb580">https://faseb.onlinelibrary.wiley.com/doi/abs/1...
Melatonin modulates granulocytes and decreases their migration https://academic.oup.com/intimm/article/27/12/597/863592">https://academic.oup.com/intimm/ar...
@farid__jalali @__ice9 Thoughts on this thread?
