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Real World Challenges in enrollment of Minorities in Clinical Trials.
Over last 2 weeks I consented 5 minorities for different clinical trials for plasma cell disorder @utswcancer. Next 5 tweets of real world examples. @theNCI @FDAOncology
Over last 2 weeks I consented 5 minorities for different clinical trials for plasma cell disorder @utswcancer. Next 5 tweets of real world examples. @theNCI @FDAOncology
1/5 - AA male in mid-50& #39;s with more than 10 lines of treatment of Myeloma, a single father of 11 yr old. Enrolled on Phase I trial, need a whole day of PK/PD, come three 3xweek- labs. On pain meds (for MM), can& #39;t drive to clinic visits. @utswcancer CRO
https://abs.twimg.com/emoji/v2/... draggable="false" alt="đ" title="Thumbs up" aria-label="Emoji: Thumbs up">. Responding Rx
2/5: AA Male s/p ASCT for #mmsm, work 50hrs/week, widower, driving distance, no family, did transplant with hired help. Consented for maintenance study but cancelled - financial hardship, misinformed by community member that trials are hoaxhttps://abs.twimg.com/emoji/v2/... draggable="false" alt="âčïž" title="Stirnrunzelndes Gesicht" aria-label="Emoji: Stirnrunzelndes Gesicht">. Can get better rx outside trial !
3/5 AA male relapsed early post ASCT were outcomes are dissimal without trials. Lives 10hrs from Comp Cancer Center, single, will loose job if any more holidays. @utswcancer - got him on #CAR T trial being leucopheresed today ! Lots ofhttps://abs.twimg.com/emoji/v2/... draggable="false" alt="đ”" title="Banknote mit Dollar-Zeichen" aria-label="Emoji: Banknote mit Dollar-Zeichen">aid, convience employers, https://abs.twimg.com/emoji/v2/... draggable="false" alt="đ€" title="Crossed fingers" aria-label="Emoji: Crossed fingers">on CART journey
4/5 Elderly AA female with diabetes, RVD, DPD, DKD in just 18 months, poor outcomes on SOC Rx. Got on Phase I/II trial - excluded for CrCl. AA - higher renal involvement. https://themmrf.org/2019/08/26/multiple-myeloma-in-african-americans/">https://themmrf.org/2019/08/2... Why so restrictive in MM ? @FDAOncology exclusion criteria should be disease specifi
5/5: Older male with newly diagnosed Amyloidosis going on trial with various biomakers/correlatives. Patient share this with me: https://www.survivornet.com/articles/why-many-african-americans-dont-trust-clinical-trials/">https://www.survivornet.com/articles/... . Hours of discussion, pt denied study due to concern blood samples can be misused. @theMMRF @IMFmyeloma
As an individual doctor, I felt defeated ! I failed at so many levels, despite my small success. We need societal changes, financial measures, policy changes, community education and team work if we want REAL CHANGE. @ASCO @ASH_hematology @NIHDirector @BarackObama @MichelleObama
@bmsnews @Merck @GSK @TakedaPharma @Amgen @pfizer @JanssenUS et al. Y& #39;all need to work together as industry leaders while academia and public continues to bring change.
