Read on Twitter
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
How it started: How it’s going:
Answers:
1. Dapsone induced methemoglobinemia (
)
2. Pentamidine
increased insulin secretion hypoglycemia
3. Succinylcholine induced malignant hyperthermia, Tx - dantrolene, supportive care
4. PPI impaired intestinal Mag absorption hypomagnesemia
1. Dapsone induced methemoglobinemia (
)2. Pentamidine
increased insulin secretion hypoglycemia3. Succinylcholine induced malignant hyperthermia, Tx - dantrolene, supportive care
4. PPI
impaired intestinal Mag absorption hypomagnesemia
5. Metformin - B12 deficiency
Mechanisms:
-alterations in small bowel motility stimulates bacterial overgrowth
-competitive inhibition/inactivation of vitamin B12 absorption
-alterations in intrinsic factor levels
-inhibition of Ca-dependent absorption at the terminal ileum
Mechanisms:
-alterations in small bowel motility
stimulates bacterial overgrowth-competitive inhibition/inactivation of vitamin B12 absorption
-alterations in intrinsic factor levels
-inhibition of Ca-dependent absorption at the terminal ileum
6. Natalizumab prevents lymphocytes from adhering to the endothelium of the blood–brain barrier reduces migration from the blood into the CNS JC virus reactivation progressive multifocal leukoencephalopathy
prevents lymphocytes from adhering to the endothelium of the blood–brain barrier reduces migration from the blood into the CNS JC virus reactivation progressive multifocal leukoencephalopathy
7. Donepezil increased cardiac vagal tone and reduced cardiac sympathetic activity bradycardia
8. Daptomycin-induced eosinophilic pneumonia
9. Capecitabine - loss of fingerprints https://pubmed.ncbi.nlm.nih.gov/31558182/
increased cardiac vagal tone and reduced cardiac sympathetic activity bradycardia8. Daptomycin-induced eosinophilic pneumonia
9. Capecitabine - loss of fingerprints https://pubmed.ncbi.nlm.nih.gov/31558182/
10.Bevacizumab increase in vascular tone due to inhibition of VEGF-mediated vasodilation malignant hypertension
11.TMP/SMX - hemolytic anemia (G6PD), bite cells on smear
12.Flucytosine - bone marrow suppression, pancytopenia
13.Atazanavir - bilirubinemia, jaundice
increase in vascular tone due to inhibition of VEGF-mediated vasodilation malignant hypertension 11.TMP/SMX - hemolytic anemia (G6PD), bite cells on smear
12.Flucytosine - bone marrow suppression, pancytopenia
13.Atazanavir - bilirubinemia, jaundice
14.Allopurinol - DRESS (Drug reaction with eosinophilia & systemic symptoms)
15.Furosemide - bullous pemphigoid
16.Rifampin - Orange urine
17.Clofazimine - hyperpigmentation
18.Metronidazole - encephalopathy (Nearly all cases show lesions in the cerebellum/dentate nuclei)
15.Furosemide - bullous pemphigoid
16.Rifampin - Orange urine
17.Clofazimine - hyperpigmentation
18.Metronidazole - encephalopathy (Nearly all cases show lesions in the cerebellum/dentate nuclei)
19.Amoxicillin - AGEP (Acute generalized exanthematous pustulosis)
20.Cyclophosphamide - hemorrhagic cystitis
21.Cisplatin disordered cerebral autoregulation, endothelial damage PRES (posterior reversible encephalopathy). Symmetrical lesions in post. cerebral hemispheres
20.Cyclophosphamide - hemorrhagic cystitis
21.Cisplatin
disordered cerebral autoregulation, endothelial damage PRES (posterior reversible encephalopathy). Symmetrical lesions in post. cerebral hemispheres
22.Sildenafil selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). Also inhibits PDE6 exclusively present in rod and cone photoreceptors blue tinge to vision (cyanopsia)
23.Isoniazid - sideroblastic anemia, addition of B6 can correct the anemia
selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). Also inhibits PDE6 exclusively present in rod and cone photoreceptors blue tinge to vision (cyanopsia)23.Isoniazid - sideroblastic anemia, addition of B6 can correct the anemia
