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Anyone with experience with MR analysis can you please tell me how to calculate F statistics for the SNP instruments? I see different formulas, not sure which one is correct.
For example, this study describes a formula where you calculate the R2 first and then F.
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003288#sec008
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003288#sec008
Citation 29 in the above study actually has a slightly different formula, not sure what n here is, sample size?
https://doi.org/10.1177/0962280210394459
https://doi.org/10.1177/0962280210394459
I found this script in the github page of MRCIEU through google where the F is calculated differently, in a simple way.
https://github.com/MRCIEU/Health-and-Wellbeing-MR/blob/master/Two-sample%20MR%20Base%20script.R
https://github.com/MRCIEU/Health-and-Wellbeing-MR/blob/master/Two-sample%20MR%20Base%20script.R
@stevesphd can u help me with this doubt pls? thanks :)
