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Excited to share our last work!! An analysis of tissue-specific alternative splicing at the protein level. @PLOSCompBiol @MichaelTress @BU_CNIO @CNIC_CARDIO https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
We manually curated a set of 255 splice events detected in a large-scale tissue-based proteomics experiment and found that more than a third had evidence of significant tissue-specific differences.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
Over 95% of splice events that were tissue-specific in both proteomics and RNAseq analyses evolved at least 400 million years ago.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
The tissues in which we found most evidence for tissue-specific splicing were nervous tissues and cardiac tissues.
Genes with tissue-specific events in these two tissues had functions related to important cellular structures in brain and heart tissues.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
Genes with tissue-specific events in these two tissues had functions related to important cellular structures in brain and heart tissues.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
Our results suggest that this conserved tissue-specific alternative splicing may have played a role in the development of the vertebrate brain and heart.
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008287
