So Trump is now also receiving dexamethasone. @WHO guidelines very clear that it is to be used only “in patients with severe and critical #COVID19”. Guidelines incl. “conditional recommendation not to use corticosteroid therapy in patients with non-severe #COVID19”.

Idea is not to reduce the immune system’s ability to fight the virus. But in later stages of severe disease, it’s the immune system itself that is creating most of the damage so sensible to dampen it down. Wondering if idea is that infused antibodies change that equation?

Any thoughts? @BhadeliaMD @MartinLandray

You know what rationale would be @Craig_A_Spencer?

Here’s his take: https://twitter.com/craig_a_spencer/status/1312783564111568896

This is @carlzimmer making the same point: https://twitter.com/carlzimmer/status/1312789495083929600

And this is a really interesting perspective too: https://twitter.com/adamcifu/status/1312429504627908609

Fair point - as usual - from Jeremy here arguing the terms “severe” or “critical” may not be very useful. Point is whether the patient needs oxygen https://twitter.com/jeremyfarrar/status/1312797183419322369