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1) Calorie excretion is an overlooked aspect of energy balance!
In this mini-review published in the new issue of @Trends_Endo_Met, @Z_GerhartHines, @ClemmensenC and I highlight how energy excretion might impact human body weight. Short thread
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(20)30134-X
In this mini-review published in the new issue of @Trends_Endo_Met, @Z_GerhartHines, @ClemmensenC and I highlight how energy excretion might impact human body weight. Short thread
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(20)30134-X
2) Variation in body weight is often ascribed to differences in energy expenditure and food intake.
Yet, not all ingested calories are taken up by the gut, and even if they are, they can still escape the body e.g. via urine. But, does it matter?
https://academic.oup.com/nutritionreviews/article/75/1/37/2684502
Yet, not all ingested calories are taken up by the gut, and even if they are, they can still escape the body e.g. via urine. But, does it matter?
https://academic.oup.com/nutritionreviews/article/75/1/37/2684502
3) Potentially, yes! Studies show that fecal energy loss vary a lot between people.
While some only drop 1-2% down the toilet drain, others excrete up to 10% of the energy they ingest!
See these two papers in @AJCNutrition: https://pubmed.ncbi.nlm.nih.gov/7282620/ & https://pubmed.ncbi.nlm.nih.gov/21543530/
While some only drop 1-2% down the toilet drain, others excrete up to 10% of the energy they ingest!
See these two papers in @AJCNutrition: https://pubmed.ncbi.nlm.nih.gov/7282620/ & https://pubmed.ncbi.nlm.nih.gov/21543530/
4) Earlier this year, Basolo et al. showed a similar variation between people in the context of 150% overfeeding. See: https://www.nature.com/articles/s41591-020-0801-z
In this study, one person excreted ~500 kcal/day, while another volunteer displayed a fecal energy loss of only ~80 kcal/day.
In this study, one person excreted ~500 kcal/day, while another volunteer displayed a fecal energy loss of only ~80 kcal/day.
5) We highlight how this changes the level of overfeeding from 150% to 135% and 147%, respectively.
This matters - possibly a lot - and leads to the hypothesis that individual differences in fecal energy loss partly explain why some easily weight gain, while others stay thin.
This matters - possibly a lot - and leads to the hypothesis that individual differences in fecal energy loss partly explain why some easily weight gain, while others stay thin.
6) So, to conclude:
The size of our fat depots is not something we decide. It’s something that’s biologically determined and controlled, not only by appetite hormones and heat production, but possibly also by calorie excretion.
#stopweightstigma @Metabolcenter @DDA_Denmark
The size of our fat depots is not something we decide. It’s something that’s biologically determined and controlled, not only by appetite hormones and heat production, but possibly also by calorie excretion.
#stopweightstigma @Metabolcenter @DDA_Denmark
