Our study out on the characteristics of effusions among patients with HHV8/KSHV-associated diseases and HIV out in @AIDS_Journal.

https://journals.lww.com/aidsonline/Abstract/9000/Elevated_IL_13_in_effusions_of_patients_with_HIV.96598.aspx

What does this mean?

Say you are a physician seeing an inpatient with Kaposi sarcoma and an effusion... 1/4

The tendency is to think that the effusion may be related to an....
1) Infection. Right? Yes, maybe. You should always check for that.
2) Kaposi sarcoma. Possible - there were descriptions of chylothorax effusions of PLWH and KS in the late 1980s ( https://pubmed.ncbi.nlm.nih.gov/2766805/ ) 2/4

In our paper we looked at patients who had Kaposi sarcoma AND another KSHV-associated disease such as primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) or KSHV-associated inflammatory cytokine syndrome (KICS), because they can happen at the same time. 3/4

We found distinct cytokine differences in the effusions of patients with KS+PEL as compared with those who had KS+MCD or KS+KICS.

Take away: Investigate effusions in patients diagnosed with HIV and KS as there could be another KSHV-associated condition that needs treatment. 4/4