Read on Twitter#COVID19 #SARSCoV2 https://www.washingtonpost.com/health/2020/09/23/houston-coronavirus-mutations/?arc404=true&no_nav=true&tid=a_classic-iphone&p9w22b2p=b2p22p9w00098">https://www.washingtonpost.com/health/20...
This mutation affects the #coronavirus spike proteināchanges amino acid 614 from āDā (aspartic acid) to āGā (glycine)āand is associated with a higher viral load in #COVID19 patients on initial diagnosis.
A larger study in the UK had similar findings. https://www.medrxiv.org/content/10.1101/2020.09.22.20199125v1">https://www.medrxiv.org/content/1...
A larger study in the UK had similar findings. https://www.medrxiv.org/content/10.1101/2020.09.22.20199125v1">https://www.medrxiv.org/content/1...
All viruses accumulate genetic mutations, and most are insignificant. #SARSCoV2 is relatively stable as viruses go.
But every mutation is a roll of the dice, and with widespread transmission in the US, the virus has had abundant opportunities to change.
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But every mutation is a roll of the dice, and with widespread transmission in the US, the virus has had abundant opportunities to change.
Some good news: None of these mutationsāincluding in spike proteināappear to have made the #coronavirus deadlier.https://abs.twimg.com/emoji/v2/... draggable="false" alt="šš¼" title="Folded hands (mittelheller Hautton)" aria-label="Emoji: Folded hands (mittelheller Hautton)">
#COVID19 #SARSCoV2
#COVID19 #SARSCoV2
This could put us in the same situation as with flu, where we have to chase the virus and, as it mutates, tinker with our vaccine.
These new genetic data show the #SARSCoV2 virus arrived in Houston many timesā71% of the viruses that arrived initially were characterized by the D614G mutation originating in #China that scientists increasingly suspect may give the virus a biological advantage in spreading.https://abs.twimg.com/emoji/v2/... draggable="false" alt="š·" title="Gesicht mit Mundschutz" aria-label="Emoji: Gesicht mit Mundschutz">
By the 2nd wave of Houstonās outbreak, the D614G variant leaped to 99.9% prevalenceādominating the outbreak. The researchers found that people infected with this strain had higher loads of virus in their upper respiratory tracts, potentially making the virus more transmissible.https://abs.twimg.com/emoji/v2/... draggable="false" alt="š·" title="Gesicht mit Mundschutz" aria-label="Emoji: Gesicht mit Mundschutz">
An even larger study of the spread of the #coronavirus in the UK, based on ~25,000 genomes, also found evidence that this variant of the virus outdistances its competitors āin a manner consistent with a selective advantage.ā
These mutations occur randomly as #SARSCoV2 makes mistakes trying to copy its genomeāand every new infection gives a chance for more mutations, which in turn increases the chance that one of these mutations will be useful to the virus, just as D614G apparently already has been.
Bottom line: allowing #SARSCoV2 to spread like wildfire not only endangers human lives in the near term, but also gives the virus more shots on goal to mutate and become more contagious and/or deadly.https://abs.twimg.com/emoji/v2/... draggable="false" alt="š·" title="Gesicht mit Mundschutz" aria-label="Emoji: Gesicht mit Mundschutz">
#coronavirus #COVID19
#coronavirus #COVID19
