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BREAKING: Massive study of more than 5,000 genetic sequences of the #coronavirus reveals continual viral mutationsāone mutation in the gene encoding its spike protein may have made the virus MORE CONTAGIOUS.
#COVID19 #SARSCoV2 https://www.washingtonpost.com/health/2020/09/23/houston-coronavirus-mutations/?arc404=true&no_nav=true&tid=a_classic-iphone&p9w22b2p=b2p22p9w00098
This mutation affects the #coronavirus spike proteināchanges amino acid 614 from āDā (aspartic acid) to āGā (glycine)āand is associated with a higher viral load in #COVID19 patients on initial diagnosis.
A larger study in the UK had similar findings. https://www.medrxiv.org/content/10.1101/2020.09.22.20199125v1
A larger study in the UK had similar findings. https://www.medrxiv.org/content/10.1101/2020.09.22.20199125v1
All viruses accumulate genetic mutations, and most are insignificant. #SARSCoV2 is relatively stable as viruses go.
But every mutation is a roll of the dice, and with widespread transmission in the US, the virus has had abundant opportunities to change.
But every mutation is a roll of the dice, and with widespread transmission in the US, the virus has had abundant opportunities to change.
Some good news: None of these mutationsāincluding in spike proteināappear to have made the #coronavirus deadlier.
#COVID19 #SARSCoV2
#COVID19 #SARSCoV2
As people gain immunityāeither via infection or a #vaccineāthe virus could be under selective pressure to evade the human immune response.This could put us in the same situation as with flu, where we have to chase the virus and, as it mutates, tinker with our vaccine.
These new genetic data show the #SARSCoV2 virus arrived in Houston many timesā71% of the viruses that arrived initially were characterized by the D614G mutation originating in #China that scientists increasingly suspect may give the virus a biological advantage in spreading.
By the 2nd wave of Houstonās outbreak, the D614G variant leaped to 99.9% prevalenceādominating the outbreak. The researchers found that people infected with this strain had higher loads of virus in their upper respiratory tracts, potentially making the virus more transmissible.
An even larger study of the spread of the #coronavirus in the UK, based on ~25,000 genomes, also found evidence that this variant of the virus outdistances its competitors āin a manner consistent with a selective advantage.ā
These mutations occur randomly as #SARSCoV2 makes mistakes trying to copy its genomeāand every new infection gives a chance for more mutations, which in turn increases the chance that one of these mutations will be useful to the virus, just as D614G apparently already has been.
Bottom line: allowing #SARSCoV2 to spread like wildfire not only endangers human lives in the near term, but also gives the virus more shots on goal to mutate and become more contagious and/or deadly.
#coronavirus #COVID19
#coronavirus #COVID19
