The therapeutic action of our candidate drug 2OHOA is based on #Melitherapy This exploits the interactions between lipids and proteins that happen in the cell membrane. Want to know more? Follow the thread!

There is something that all the cells in our body have in common: they all have a membrane that separates them from the outside This is made of a double layer of lipids that have proteins embedded in it.

These proteins play many important roles: they allow the cell to let molecules in and out and also to communicate with other cells and the outside

Some of these proteins act as receptors for chemical signals that produce relevant changes in the cell For example, they can receive a signal that makes the cell to divide, to change the expression of their genes or even to die

Sometimes these changes are behind the onset of some diseases An example of this is #cancer: if the signals that make the cells divide get unbalanced, they start to do so out of control, producing a tumour.

Here is where #Melitherapy can make the difference! This therapy targets the lipids that form the membrane.

Proteins need a certain interaction with membrane lipids to stay in it. It the lipids change, proteins may lose their hook and enter the membrane. Thus, they would stop receiving any signal

To sum up, if we manage to change at will the composition of the cellular membrane, we can control the signals that the cell receives and stop those that are producing the disease

And this may be useful for #glioblastoma, as some signalling pathways related to cell proliferation happen through the cell membrane!

If you want to know how we take advantage of this novel approach, visit our webpage! http://clinglio.eu