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Ustekinumab, brand name Stelara, associated with increase in serious cardiovascular events.
If an immune suppressant increases these risks, it implies that the underlying disease could be driven by infection.
Most patients in the study had psoriasis.
https://www.hcplive.com/view/ustekinumab-associated-increased-risk-serious-cardiovascular-events
If an immune suppressant increases these risks, it implies that the underlying disease could be driven by infection.
Most patients in the study had psoriasis.
https://www.hcplive.com/view/ustekinumab-associated-increased-risk-serious-cardiovascular-events
Psoriasis is known to be associated with an increased risk for heart disease.
Why? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898839/
Why?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898839/
Psoriasis has been known to develop in bartonella patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637281/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637281/
Bartonella can damage the lining of arteries in a unique way, suggesting that this infection may increase the risk for cardiovascular disease. https://pubmed.ncbi.nlm.nih.gov/26066633/
https://pubmed.ncbi.nlm.nih.gov/26066633/
Bartonella infection may be associated with HLA-B27, an immune system type associated with spondylitis (arthritis of the spine) & uveitis (inflammation of the eye).
Psoriatic patients are at increased risk for spondylitis & uveitis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723263/
Psoriatic patients are at increased risk for spondylitis & uveitis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723263/
Rifampin, an antibiotic active against bartonella, improves psoriasis.
Some posit that it's due to mild immunosuppressive effects, but patients who are unresponsive to more powerful immunosuppressives have responded to rifampin. https://www.tandfonline.com/doi/abs/10.3109/09546639209089062?journalCode=ijdt20
Some posit that it's due to mild immunosuppressive effects, but patients who are unresponsive to more powerful immunosuppressives have responded to rifampin. https://www.tandfonline.com/doi/abs/10.3109/09546639209089062?journalCode=ijdt20
Double-blind, RCT using ceftriaxone, an antibiotic without immunosuppressive action, demonstrated benefits to psoriatic arthritis.
Therefore, it must be due to its antimicrobial action. https://pubmed.ncbi.nlm.nih.gov/2383162/
Therefore, it must be due to its antimicrobial action. https://pubmed.ncbi.nlm.nih.gov/2383162/
It makes healthier sense to look to the cause of chronic disease, and not just treat the symptoms.
Is any pharma company motivated to do this when instead they can receive an annuity from a lifetime of symptom suppression?
#NoMoneyInCures
Is any pharma company motivated to do this when instead they can receive an annuity from a lifetime of symptom suppression?
#NoMoneyInCures
