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Do we know that there is 13 scientific evidence already that confer a direct association between #VitaminD deficiency & #COVID19 disease severity-mortality? Yet, no standard guidelines available at the national or international level for common people. THREAD must read and share.
1. Latest trial from Spain with 76 COVID 19 patients found that calcifediol (active form of Vit-D) reduced ICU admission & mortality in 50 patients treated w/calcifediol. only 1 among these 50 needed ICU admission in comparison to 13/26 w/out intervention. https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#tbl0005
2. A cohort study reported that only 17.6% of patients required oxygen who received Vit-D, magnesium & B12 combination in comparison with 61.5% who didn't receive this combination.
https://www.medrxiv.org/content/10.1101/2020.06.01.20112334v2
https://www.medrxiv.org/content/10.1101/2020.06.01.20112334v2
3. A study from Iran found significant alterations in vitamin D and ACE levels as well as NLR (neutrophil to lymphocyte ratio) in the patients’ group. The contribution of those factors with the prognosis and severity of the disease has been shown.
https://www.sciencedirect.com/science/article/pii/S0168170220310558
https://www.sciencedirect.com/science/article/pii/S0168170220310558
4. In 70 patients, researchers observed more Vitamin D deficiency among COVID positive patients and concluded worse morbidity outcomes may be seen in older adults with vitamin D deficiency and COVID-19. https://pmj.bmj.com/content/early/2020/08/26/postgradmedj-2020-138712?rss=1
5. A retrospective, observational study with 42 patients revealed that after 10 days of hospitalization, severe vitamin D deficiency patients had a 50% mortality probability, while those with vitamin D ≥10 had a 5% mortality risk.
https://assets.researchsquare.com/files/rs-41173/v1/0e401c21-0b76-4f69-8cf5-0f83dfb135d3.pdf
https://assets.researchsquare.com/files/rs-41173/v1/0e401c21-0b76-4f69-8cf5-0f83dfb135d3.pdf
6. A hospital data of 235 patients from Iran showed Vitamin D sufficiency reduced risk for morbidity and mortality in COVID-19 Patients.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3616008
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3616008
7. A Mexican study with 172 COVID 19 patients demonstrated patients with vitamin D serum levels below 8 ng/mL had a 3.68 higher risk of dying from COVID-19.
https://www.medigraphic.com/pdfs/sanmil/sm-2020/sm201_2za.pdf
https://www.medigraphic.com/pdfs/sanmil/sm-2020/sm201_2za.pdf
8. A retrospective analysis in hospitalized COVID 19 patients found that patients requiring ITU admission were more frequently vitamin D deficient than those managed on medical wards, despite being significantly younger. https://www.medrxiv.org/content/10.1101/2020.06.21.20136903v2
9. A study from Belgium with 186 patients concluded vitamin D deficiency is a prevalent risk factor for severe COVID-19. Vitamin D supplementation might be inexpensive and safe mitigation for the SARS-CoV-2 pandemic. https://www.medrxiv.org/content/10.1101/2020.05.01.20079376v2
10. Swiss study with 107 COVID 19 patients found significantly lower 25(OH)D levels in PCR-positive for SARS-CoV-2 compared with negative patients (24.6 ng/mL)
https://www.mdpi.com/2072-6643/12/5/1359/htm
https://www.mdpi.com/2072-6643/12/5/1359/htm
11. Among 4,314 patients from Chicago tested for COVID-19 those with pre-existing Vitamin D deficiency were more likely to test positive for the disease in comparison to those who were having a sufficient level of Vitamin D.
https://www.medrxiv.org/content/10.1101/2020.05.08.20095893v1.full.pdf
https://www.medrxiv.org/content/10.1101/2020.05.08.20095893v1.full.pdf
12. A population-based study among 4.6 million members of Clalit Health Services (CHS) in Israel showed a strong association between vitamin D deficiency and Covid-19 occurrence. Vitamin D tests performed between 2010 and 2019. https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1
13. Israeli study in 7807 COVID 19 patients demonstrated an association between the low plasma 25(OH)D level and increased likelihood of COVID‐19 infection and of hospitalization due to the SARS‐CoV‐2 virus https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15495
