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1/5
One of the things I find really exciting in modern #biology is the scale of the datasets, and how we can generate them in such diversity
https://abs.twimg.com/emoji/v2/... draggable="false" alt="🤩" title="Vom Star geblendet" aria-label="Emoji: Vom Star geblendet"> #singlecell #omics
Just look at the recent slew of #GTEX papers - amazing!
One of the things I find really exciting in modern #biology is the scale of the datasets, and how we can generate them in such diversity
Just look at the recent slew of #GTEX papers - amazing!
2/5
There& #39;s often a bit of a tension between "hypothesis driven" vs "big data science"
I& #39;ve occasionally been disappointed by accusations of "fishing expeditions", "stamp collecting", or doing "descriptive" work.
Of course the reality is that the approaches should co-exist..
There& #39;s often a bit of a tension between "hypothesis driven" vs "big data science"
I& #39;ve occasionally been disappointed by accusations of "fishing expeditions", "stamp collecting", or doing "descriptive" work.
Of course the reality is that the approaches should co-exist..
3/5
This lovely (and fair handed) commentary puts the lofty place of the hypothesis in the scientific method into perspective.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02133-w#:~:text=There%20is%20a%20hidden%20cost%20to%20having%20a%20hypothesis.&text=But%20when%20we%20analyze%20the,for%20any%20night%20science%20explorations.">https://genomebiology.biomedcentral.com/articles/...
This lovely (and fair handed) commentary puts the lofty place of the hypothesis in the scientific method into perspective.
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02133-w#:~:text=There%20is%20a%20hidden%20cost%20to%20having%20a%20hypothesis.&text=But%20when%20we%20analyze%20the,for%20any%20night%20science%20explorations.">https://genomebiology.biomedcentral.com/articles/...
4/5
@ItaiYanai & M Lercher distinguish "https://abs.twimg.com/emoji/v2/... draggable="false" alt="☀️" title="Sonne mit Strahlen" aria-label="Emoji: Sonne mit Strahlen">Day science" - busy falsifying hypotheses & "https://abs.twimg.com/emoji/v2/... draggable="false" alt="🌜" title="Dreiviertelmond mit Gesicht" aria-label="Emoji: Dreiviertelmond mit Gesicht">Night science" - exploring data freely, looking closely at the data, mindful of the field. Are the observed patterns surprising or unknown?
Exploratory analysis canhttps://abs.twimg.com/emoji/v2/... draggable="false" alt="➡️" title="Pfeil nach rechts" aria-label="Emoji: Pfeil nach rechts"> unexpected discovery!
@ItaiYanai & M Lercher distinguish "
Exploratory analysis can
5/5
Their advice not to give up on a dataset ishttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🌲" title="Immergrüner Baum" aria-label="Emoji: Immergrüner Baum">evergreenhttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🌲" title="Immergrüner Baum" aria-label="Emoji: Immergrüner Baum">.
Your hypothesis might be keeping you from seeing the Gorilla in the data ;)
Their advice not to give up on a dataset is
Your hypothesis might be keeping you from seeing the Gorilla in the data ;)
evergreenhttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🌲" title="Immergrüner Baum" aria-label="Emoji: Immergrüner Baum">.Your hypothesis might be keeping you from seeing the Gorilla in the data ;)" title="5/5Their advice not to give up on a dataset ishttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🌲" title="Immergrüner Baum" aria-label="Emoji: Immergrüner Baum">evergreenhttps://abs.twimg.com/emoji/v2/... draggable="false" alt="🌲" title="Immergrüner Baum" aria-label="Emoji: Immergrüner Baum">.Your hypothesis might be keeping you from seeing the Gorilla in the data ;)" class="img-responsive" style="max-width:100%;"/>
