Giving talks in which you don& #39;t have a slide deck already made is illuminating. Look what I found out about publication bias>
It was "discovered" in 1979 by Rosenthal https://content.apa.org/record/1979-27602-001
How">https://content.apa.org/record/19... did he do this?
Thread ...
It was "discovered" in 1979 by Rosenthal https://content.apa.org/record/1979-27602-001
How">https://content.apa.org/record/19... did he do this?
Thread ...
He used a variant of ...sit down for this...the Fragility Index, which we reported on in cardiology
https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.119.005755
The">https://www.ahajournals.org/doi/10.11... criticism was fierce. But I liked it. @ShahzebKhanMD
https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.119.005755
The">https://www.ahajournals.org/doi/10.11... criticism was fierce. But I liked it. @ShahzebKhanMD
Here& #39;s Rosenthal& #39;s explanation
I am no stats person but this looks a lot like a fragility concept applied to all studies.
I am no stats person but this looks a lot like a fragility concept applied to all studies.
Rosenthal& #39;s conclusion -- prescient.
Here is Steve Nissen in 2013 in @JAMAInternalMed https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/1672288?appId=scweb">https://jamanetwork.com/journals/...
Clinical trial registration has probably got us to a better place now. But still, I think this supports a #medicalconservative approach to evidence translation.
Happy to hear thoughts on this from anyone. cc @kaulcsmc @gcfmd @AndrewFoy82 @califf001
@LuisCLCorreia
Happy to hear thoughts on this from anyone. cc @kaulcsmc @gcfmd @AndrewFoy82 @califf001
@LuisCLCorreia
I know @eturnermd1 has a wonderful paper in NEJM on this issue with anti-depressant drugs
(I wonder if most patients know about this? These drugs are super common) https://www.nejm.org/doi/full/10.1056/nejmsa065779">https://www.nejm.org/doi/full/...
(I wonder if most patients know about this? These drugs are super common) https://www.nejm.org/doi/full/10.1056/nejmsa065779">https://www.nejm.org/doi/full/...