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Time for some writing real talk. I was talking to a fellow author today about how tough it is having no idea how things are going to work out. That's the case for a lot of things sure, but there are very few pieces of creative work that require the stamina of writing a novel.
I recently wrote a humourous science fiction novel which I describe as the result of being raised on a diet of Terry Pratchett and Star Trek. As soon as I finished it I thought, this is my meal ticket book, it's light years better than anything else I've ever written.
Last year I parted ways with my agent so I had to go back into the query trenches with the manuscript. Everyone who reads it seems to love it, agents and publishers included, and then when I sent the book out into the wild...absolute donuts.
It went to acquisitions at a big publisher but was ultimately rejected. It got a lot of full requests from agents but all of them passed. The reason stated by all of them, it's science fiction with comedy. It's too hard to sell.
Personally, I love humorous sci-fi in the Douglas Adams/Red Dwarf vein. To me, science fiction and absurdism are perfectly matched. Still, I'm not writing this to bemoan publishing's opinion of whether a certain genre will sell. I'm saying being an author is so unpredictable.
I poured years into this book, I think it's my best work and I cannot sell it. To contrast that, a little while ago I reached out with a cold message to an acquaintance to chat about Warhammer 40k fiction, next minute I'm writing full length novels for Black Library. 
Anyway, the point of this thread is to say it's super hard to predict anything in this writing game and it's worth remembering to try and focus on the journey rather than the destination or some other thing they'd write on an inspirational poster of a mountain.
And for you wonderful people who've said you agree that science fiction comedy is awesome, this book will find its way into the world even if I have to drag it kicking and screaming by the inertial dampers (read: publish it myself).
