Read on Twitter
1/ New thread! From the previous thread ( https://twitter.com/Gurdur/status/1302348677223153670). Now the tricky, tricky question of ACE inhibitors (ACEi), used mostly in treatment of high blood pressure and congestive heart failure; are they a bad idea with #COVID19? A risk?
2/n From the Medium post ( https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63). So severe #COVID19 is like an ACE inhibitor on meth; clearly, if you get at all ill with COVID_19, see your doc immediately if you're on ACE inhibitors (e.g. benazepril, zofenopril, perindopril, trandolapril, enalapril, etc.)
3/n In my terribly simplistic view, being ill with #COVID19 means not having to take your usual ACEi. But very seriously, you need to talk with a real doc in that situation; consult too with those like @PathogenScribe, @DrJudyStone, @evolutionarypsy, @ChristosArgyrop, @rckiser
4/n Next problem for me: the Medium report talks of increased blood potassium (tweet 3 above), but the paper talks of systemic hypokalemia (see quote-tweet), so I'm a bit at sea about what's happening there.
( https://twitter.com/Gurdur/status/1302348677223153670)
( https://twitter.com/Gurdur/status/1302348677223153670)
5/ yes exactly. So one really needs to know why, and that hasn't been adequately addressed in the bradykinin paper or Medium post on that, AFAIK https://twitter.com/bealelab/status/1302359335633326082
6/ Taking Wikipedia as a source for the moment; again the parallels between ACEi's and #COVID19. Yes, the parallels are striking; but the point raised in the previous tweet remains. So the question is very open?!
7/n One last bit on the RAS system and bradykinin hypothesis, before we get onto the more exciting bits, like, what can we do about it?
Reminder: as you see in THIS thread, there are huge questions, possible contradictions, as yet unanswered.
Anyway, sex matters!
Reminder: as you see in THIS thread, there are huge questions, possible contradictions, as yet unanswered.
Anyway, sex matters!
