Marie de Guise lived from 22 November 1515 to 11 June 1560. She was the daughter of Claude, Duke of Guise. At the age of 19 Marie married Louis of Orleans, Duke of Longueville and the following year they had a son, Francis

On 1 January 1537, Marie attended the wedding of James V of Scotland and Madeleine de Valois, the daughter of King Francis I of France. On 9 June 1537, Marie's husband Louis died, and on 4 August 1537 Marie gave birth to her second son, named Louis after his father

Meanwhile Madeleine de Valois had died in July 1537 and James V renewed his search for a bride capable of cementing the ties between Scotland and France. Marie de Guise was the obvious candidate and James V asked Francis I of France for Marie's hand in marriage.

Henry VIII ofEngland sought to prevent what would be a dangerous alliance for England by himself askingFrancis I for Marie's hand. Marie,who was by now also grieving the loss of her youngest son Louis, did not relish being the focus of a diplomatic argument that could lead to war

The King of France accepted the proposal of James V of Scotland, and James overcame Marie's reluctance with a letter in which he tried to, in modern football parlance, "agree personal terms". Marie was married by proxy to James V on 18 May 1538 at Notre-Dame de Paris,

and sailed to Scotland,

where she and James were married in person at St Andrews in June 1538.

Marie was crowned Queen Consort at Holyrood Abbey in Edinburgh on 22 February 1540.

Marie married James, and they had two sons, James and Robert, who both died in infancy. Their daughter, Mary, was born on 8 December 1542 at Linlithgow Palace. On 14 December 1542, James V died, leaving their infant daughter to become Mary Queen of Scots,

and Marie de Guise as Regent of Scotland.

At the age of 27 she had been married twice, widowed twice, lost four children in infancy, and now found herself ruler of a foreign country on behalf of her baby daughter.
More at
https://www.undiscoveredscotland.co.uk/usbiography/g/mariedeguise.html