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Had some more time with the clinical trials EMPEROR-Reduced and DAPA-CKD and was able to compute various composite outcomes from the major SGLT2i trials.
Just posting the results here : if you don't start using to save lives/hearts/kidneys after this data, you are beyond fix
Just posting the results here : if you don't start using to save lives/hearts/kidneys after this data, you are beyond fix
All Cause Mortality
Cardiovascular Mortality
Hospitalization for Heart Failure (HHF)
Worsening renal function (typically >40% sustained eGFR decline) or End Stage Kidney Disease (ESKD)
Worsening renal function/ESKD or renal death (composite kidney, did not find any "renal deaths" in EMPEROR, so made it equal to worsening renal function/ESKD)
Very few renal deaths in any of the trials, so almost the same as the previous one
Very few renal deaths in any of the trials, so almost the same as the previous one
Composite of decr renal function/ESRD or death from all causes (this required an intermediate meta-analytic step of the individual components within each trial as it was not reported for most trials)
VERTIS CV is missing because I could not find all cause death from this RCT
VERTIS CV is missing because I could not find all cause death from this RCT
Composite Cardiorenal: composite of worsening kidney function/ESKD and death
End of twitter meta-analysis. I am leaving the figures here if you want to use them for presentations.
May or may credit my handle
May or may credit my handle
*May or may not*
