Thread by @TristanRutland7, Testis@ZHOUSEH @MattieFarzin @DrGeeONE @Teclis82 @WebPathology @Kashifhazim @MAHoureih @Meghna0630 @Divya_Madhala #GUPath #PathTwitter #surgpath [...]

Testis

@ZHOUSEH @MattieFarzin @DrGeeONE @Teclis82 @WebPathology @Kashifhazim @MAHoureih @Meghna0630 @Divya_Madhala

#GUPath #PathTwitter #surgpath

Another image

High power view of nodule on the right hand side.

Inhibin

Pancytokeratin

Other stains that were done:

CD30 - negative

AFP - negative

CD117

PLAP

Diagnosis:

Seminoma with “tubular” pattern.

1/ There are a number of rarer patterns a seminoma can have including tubular, tubulopappilary, cordlike or microcystic.

2/ thus the main DDx for this case would have been sertoli cell, yolk sac or carcinoid tumour for this pattern. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1440-1827.1999.00919.x

Tubular seminoma of the testis

A case of tubular seminoma in a 33‐year‐old man is reported. The tumor occurred in his right testis, measuring 7 × 6 × 6 cm in size. Microscopically, most of the tumor cells were arranged in solid...

https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1440-1827.1999.00919.x

3/ There is no really prognostic difference with this pattern.
https://academic.oup.com/ajcp/article-abstract/102/4/397/1755411?redirectedFrom=fulltext

Tubular Seminoma: An Immunohistochemical and DNA Flow-cytometric Study of Four Cases

Abstract. The histomorphologic features, immunohistochemical reactivity, and DNA content of four cases of a rare tubular variant of seminoma are presented. The

https://academic.oup.com/ajcp/article-abstract/102/4/397/1755411?redirectedFrom=fulltext

4/ Lastly, this case also had classic changes of cryptorchidism (see images below).

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