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Found this absolute gem thanks to @AmeliaJScott - Part 1 argues for an experimental approach to mechanisms of psych tx... Some thoughts/ take aways
(1/n) https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30513-8/fulltext">https://www.thelancet.com/journals/...
(1/n) https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30513-8/fulltext">https://www.thelancet.com/journals/...
There& #39;s been a shift in the field away from mechanistic, experimental treatment designs and instead towards adapting protocols for diff presentations/ settings... While useful, lacks a mechanistic understanding (2/n)
Mediation analyses are not the be all and end all when it comes to understanding if a mechanism is actually causal - need a stronger case than this (3/n)
We& #39;ve made a lot of progress re moderators of psych tx outcome - e.g. the case of DCS and exposure https://ja.ma/350SqP0 ">https://ja.ma/350SqP0&q...
Mechanism research can avoid "one size fits all" tx approaches... Which parts of tx do we modify? And for whom? (5/n)
We can use a mechanistic approach to see which tx modules work for whom, and whether tailoring tx works - e.g. @DrMelissaBlack and colleagues modular transdx tx trial (6/n) https://bmjopen.bmj.com/content/8/8/e024546">https://bmjopen.bmj.com/content/8...
Key to all of this is bringing basic science and clinical researchers together... A huge gap exists, and communication between the two is needed for translation (7/n)
There& #39;s a huge opportunity for clinical research to embrace experimental approaches to identify mechanisms of tx... a very exciting prospect (8/8)
