Thread by @f_g_zampieri, So @JAMA_current is having a blast of corticosteroid papers for COVID-19 today [...]

Fernando Zampieri

f_g_zampieri

So @JAMA_current is having a blast of corticosteroid papers for COVID-19 today and I strongly recommend you have a look.

You can start with the WHO metanalysis that summarizes everything up: https://jamanetwork.com/journals/jama/article-abstract/2770279">https://jamanetwork.com/journals/...

Association Between Systemic Corticosteroids and Mortality Among Critically Ill Patients With...

This meta-analysis pools data from 7 randomized trials to estimate the association between administration of corticosteroids vs usual care or placebo and all-cause mortality at 28 days in patients...

https://jamanetwork.com/journals/jama/article-abstract/2770279

Then you can move forward and check @ICURevisited and @azevedo_lcp& #39;s outstanding effort in using dexamethasone for ventilated COVID-19 patients. Kudos! Great effort. https://jamanetwork.com/journals/jama/article-abstract/2770277">https://jamanetwork.com/journals/...

Effect of Dexamethasone on Ventilator-Free Days in Patients With Moderate or Severe COVID-19–Rela...

This open label clinical trial compares the effects of dexamethasone vs usual care on the number of days alive and free of mechanical ventilation at day 28 among COVID-19 patients in Brazil with...

https://jamanetwork.com/journals/jama/article-abstract/2770277

Then you can see the REMAP-CAP results which present results in a lovely Bayesian fashion way. https://jamanetwork.com/journals/jama/article-abstract/2770278">https://jamanetwork.com/journals/...

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

This open-label randomized trial compares the effects of fixed-dose vs shock-dependent vs no intravenous hydrocortisone on organ support–free days among patients with coronavirus disease 2019...

https://jamanetwork.com/journals/jama/article-abstract/2770278

Finally, but not least important, there is another cool paper by Dequin on hydrocortisone (which is far from being "negative") https://jamanetwork.com/journals/jama/article-abstract/2770276">https://jamanetwork.com/journals/...

Effect of Hydrocortisone on Mortality or Respiratory Support Among Critically Ill COVID-19 Patients

This randomized clinical trial compares the effect of low-dose hydrocortisone vs placebo on treatment failure (death or persistent respiratory support dependency) at 21 days in critically ill...

https://jamanetwork.com/journals/jama/article-abstract/2770276

Each paper has its own merit and deserves a deep look and read. I cannot commend @JAMA_current enough for putting this together in a single edition that is of pivotal importance for the community.

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