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1/22
KOCH'S POSTULATES THREAD. Sorry, long thread.
SARS-CoV-2 and Koch’s postulates. Has testing and recovery fulfilled Koch’s postulates?
1.The pathogen must be present in every case of the disease.
KOCH'S POSTULATES THREAD. Sorry, long thread.
SARS-CoV-2 and Koch’s postulates. Has testing and recovery fulfilled Koch’s postulates?
1.The pathogen must be present in every case of the disease.
2/22
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
3/22
4.The pathogen must be recoverable from the experimentally infected host.
4.The pathogen must be recoverable from the experimentally infected host.
4/22
1.The pathogen must be present in every case of the disease.
Virus isolated from first patient in Korea: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036342/
1.The pathogen must be present in every case of the disease.
Virus isolated from first patient in Korea: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036342/
5/22
1.The pathogen must be present in every case of the disease.
Infection in 7-week old baby: https://www.sciencedirect.com/science/article/pii/S1201971220303428
1.The pathogen must be present in every case of the disease.
Infection in 7-week old baby: https://www.sciencedirect.com/science/article/pii/S1201971220303428
6/22
1.The pathogen must be present in every case of the disease.
Isolated from urine: https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1760144
1.The pathogen must be present in every case of the disease.
Isolated from urine: https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1760144
7/22
1.The pathogen must be present in every case of the disease.
Isolated from serum, urine and stool: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282421/
1.The pathogen must be present in every case of the disease.
Isolated from serum, urine and stool: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282421/
8/22
1.The pathogen must be present in every case of the disease.
Isolated from first Australian patient: https://onlinelibrary.wiley.com/doi/full/10.5694/mja2.50569
1.The pathogen must be present in every case of the disease.
Isolated from first Australian patient: https://onlinelibrary.wiley.com/doi/full/10.5694/mja2.50569
9/22
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
Isolated and grown in Vero and LLC-MK2 cell culture, from a 7-week old baby: https://www.sciencedirect.com/science/article/pii/S1201971220303428
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
Isolated and grown in Vero and LLC-MK2 cell culture, from a 7-week old baby: https://www.sciencedirect.com/science/article/pii/S1201971220303428
10/22
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
Isolated from first Australian patient, grown in Vero-SLAM cell culture: https://onlinelibrary.wiley.com/doi/full/10.5694/mja2.50569
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
Isolated from first Australian patient, grown in Vero-SLAM cell culture: https://onlinelibrary.wiley.com/doi/full/10.5694/mja2.50569
11/22
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
Isolated from the first US patient, grown in Vero CCL81 cell culture: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239045/
2.The pathogen must be isolated from the host with the disease and grown in pure culture.
Isolated from the first US patient, grown in Vero CCL81 cell culture: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239045/
12/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in Syrian hamster: https://science.sciencemag.org/content/369/6506/956.full
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in Syrian hamster: https://science.sciencemag.org/content/369/6506/956.full
13/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in Rhesus macaques: https://www.nature.com/articles/s41422-020-0364-z
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in Rhesus macaques: https://www.nature.com/articles/s41422-020-0364-z
14/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in a mouse model: https://www.sciencedirect.com/science/article/pii/S1931312820303024
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in a mouse model: https://www.sciencedirect.com/science/article/pii/S1931312820303024
15/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in ferrets: https://www.sciencedirect.com/science/article/pii/S1931312820301876
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in ferrets: https://www.sciencedirect.com/science/article/pii/S1931312820301876
16/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in fruit bats, ferrets, pigs and chickens: https://www.sciencedirect.com/science/article/pii/S2666524720300896
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in fruit bats, ferrets, pigs and chickens: https://www.sciencedirect.com/science/article/pii/S2666524720300896
17/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in golden hamsters: https://www.nature.com/articles/s41586-020-2342-5
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in golden hamsters: https://www.nature.com/articles/s41586-020-2342-5
18/22
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in ferrets, cats, dogs and other domesticated animals: https://science.sciencemag.org/content/368/6494/1016.full
3.The specific disease must be reproduced when a pure culture of the pathogen is inoculated into a healthy susceptible host.
Demonstrated in ferrets, cats, dogs and other domesticated animals: https://science.sciencemag.org/content/368/6494/1016.full
19/22
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from ferrets, cats, dogs and other domesticated animals: https://science.sciencemag.org/content/368/6494/1016.full
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from ferrets, cats, dogs and other domesticated animals: https://science.sciencemag.org/content/368/6494/1016.full
20/22
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from golden hamsters: https://www.nature.com/articles/s41586-020-2342-5
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from golden hamsters: https://www.nature.com/articles/s41586-020-2342-5
21/22
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from ferrets: https://www.sciencedirect.com/science/article/pii/S2666524720300896
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from ferrets: https://www.sciencedirect.com/science/article/pii/S2666524720300896
22/22
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from ferrets: https://www.sciencedirect.com/science/article/pii/S1931312820301876
4.The pathogen must be recoverable from the experimentally infected host.
Recovered from ferrets: https://www.sciencedirect.com/science/article/pii/S1931312820301876
