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See our new @plospathogens paper with the Hinton Lab @jay_salsa on the role of the MacAB-TolC efflux pump during infection by invasive #Salmonella isolates from Africa. https://doi.org/10.1371/journal.ppat.1008763
See our new @plospathogens paper with the Hinton Lab @jay_salsa on the role of the MacAB-TolC efflux pump during infection by invasive #Salmonella isolates from Africa. https://doi.org/10.1371/journal.ppat.1008763
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Whole genome analysis of all sequenced African #iNTS isolates by @yan_salsa @NWenner and @implosian identified several variants of MacAB associated with each lineage.
Whole genome analysis of all sequenced African #iNTS isolates by @yan_salsa @NWenner and @implosian identified several variants of MacAB associated with each lineage.
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We showed these MacAB variants change resistance to the antimicrobial peptide C18G and alter #Salmonella replication in macrophages.
We showed these MacAB variants change resistance to the antimicrobial peptide C18G and alter #Salmonella replication in macrophages.
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These MacAB variants also alter relative fitness during competitive infections in the gut and in systemic sites.
These MacAB variants also alter relative fitness during competitive infections in the gut and in systemic sites.
Thanks to Susan Brewer, Sky Brubaker, @knalsal, @LilianaMassis, and Phoom Chairatana for their help on this story! Thanks as well to @Eliza_coli for the graphical abstract.
