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First case of documented #COVID19 reinfection. Second infection (asymptomatic-with elevated CRP) 142d later, by a genetically different #SARSCoV2 strain.
Implications:
- As in other coronaviruses, reinfection possible.
- Immunity from 1st may have led to milder 2nd episode?
... https://twitter.com/ABsteward/status/1298287856063000576">https://twitter.com/ABsteward...
Implications:
- As in other coronaviruses, reinfection possible.
- Immunity from 1st may have led to milder 2nd episode?
... https://twitter.com/ABsteward/status/1298287856063000576">https://twitter.com/ABsteward...
- vaccine trials should also include persons wt past COVID19.
- low antibody titres in 2nd episode might mean that seroprevalence studies underestimate?
- viral cultures pending to see Neutralizing antibodies in both episodes.
- low antibody titres in 2nd episode might mean that seroprevalence studies underestimate?
- viral cultures pending to see Neutralizing antibodies in both episodes.
Still, actual frequency of re-infection remains low and unknown (only 8 months in the pandemic), therefore future implications remain to be seen
Nice thread of thoughts on the recently published case of #SARSCoV2 reinfection https://twitter.com/kakape/status/1298038827265687558?s=19">https://twitter.com/kakape/st...
Second case of #SARSCOV2 reinfection (pre-print):
25yo, 2 episodes from genetically different strains, 48d apart
What’s different? 2nd episode was more severe (pneumonia & hypoxemia). Authors used a series of tests to confirm findings & rule out errors
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3681489
...">https://papers.ssrn.com/sol3/pape...
25yo, 2 episodes from genetically different strains, 48d apart
What’s different? 2nd episode was more severe (pneumonia & hypoxemia). Authors used a series of tests to confirm findings & rule out errors
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3681489
...">https://papers.ssrn.com/sol3/pape...
But if reinfection is common, then that’s probably good news, bc most must have gone undetected (asymptomatic or mild).
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So let’s keep our calm while we still assess the extent of this phenomenon
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- Does the level & extent of immune response during first episode affect the possibility of a second infection?
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- Similarly, could there be variable protection due to variable immune responses elicited during an initial episode? (eg.antibodies produced during an infection that can’t protect from a genetically discordant strain)?
- Can a reinfected person transmit the virus?
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- Can a reinfected person transmit the virus?
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Here’s a nice piece that explains reinfection and its possible implications https://www.statnews.com/2020/08/28/covid-19-reinfection-implications/">https://www.statnews.com/2020/08/2...
