While most now accept that metabolic dysfunction* is at the root of today's chronic disease epidemic, we can't seem to agree on what causes this in the first place.

Hint: it's not carbohydrates

Once metabolic dysfunction has occurred, humans certainly become carbohydrate intolerant, and lowering the intake of this macronutrient can be quite helpful in this situation, but it's not the root of the problem.

If carbs didn't cause the problem, what did? The most compelling evidence points to metabolic dysfunction arising at the level of fat cells (adipocytes), which become overdistended.

How did these adipocytes get so full?

Excess dietary linoleic acid.

Polyunsaturated fats caused the fire, carbohydrates just fuel the blaze. To correct the problem we have to remove both.

*Metabolic dysfunction seems to be better terminology than "insulin resistance." Though the latter term is widely used, it's an inaccurate descriptor and misses much of the important nuance. If you don't know the difference here, it's time to do your homework.