First results of REACT research out today; three papers on validity, usability & prevalence (2 published, 1 preprint) with @grahamscooke
Thread with key findings of study of 100,000 randomly selected adults who used a home test for IgG antibodies

1/6 https://www.imperial.ac.uk/medicine/research-and-impact/groups/react-study/real-time-assessment-of-community-transmission-findings/">https://www.imperial.ac.uk/medicine/...

Prevalence (England) 6.0% (95% CI: 5.8, 6.1).
Highest prevalence in
* London (13.0% [12.3, 13.6]),
* people of Black or Asian (mainly South Asian) ethnicity (17.3% [15.8, 19.1] and 11.9% [11.0, 12.8] respectively)
* Aged 18-24 years (7.9% [7.3, 8.5])
2/6

* Care home workers with client-facing roles three-fold increased odds ratio of 3.1 (2.5, 3.8) compared with non-essential workers.
* One third (32.2%, [31.0-33.4]) of antibody positive individuals reported no symptoms (almost half in 65+ yrs)
3/6

* Among symptomatic cases, the majority (79%) reported symptoms during the peak of the epidemic
* chart shows epidemic curve of the 3493 people with antibodies who had symptoms by time of their symptoms (dotted) with COVID deaths in England (solid line) which lags

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* We estimate that 3.36 million (3.21, 3.51) people have been infected with SARS-CoV-2 in England to end June 2020
* Overall infection fatality ratio of 0.90% (0.86, 0.94) varies by age and sex (table)
5/6

* SARS-CoV-2 infection in England disproportionately affected ethnic minority groups and health and care home workers.
* The higher risk of infection in these groups may explain, at least in part, their increased risk of hospitalisation and mortality from COVID-19

ENDS