Read on Twitter
1/ 
Yet another @ONDRISTUDY preprint alert!
Kelly led this all-hands team science effort that outlines exactly what the @ONDRISTUDY looks like at baseline, and goes into the breadth of neurodegenerative disorders and the depth of assessments/measurements https://twitter.com/medrxivpreprint/status/1289854905268596737
Yet another @ONDRISTUDY preprint alert!Kelly led this all-hands team science effort that outlines exactly what the @ONDRISTUDY looks like at baseline, and goes into the breadth of neurodegenerative disorders and the depth of assessments/measurements https://twitter.com/medrxivpreprint/status/1289854905268596737
2/ This work is fundamental in that it provides a perspective on the whole study from baseline, and compares the characteristics of @ONDRISTUDY with other neurodegenerative studies. Kelly's paper helps put lots of other @ONDRISTUDY papers (past, present, and future) into context
3/ WHILE WE'RE AT IT
For the rest of this thread, I'm going to link to and single-tweet summarize some of the other recent @ONDRISTUDY papers and preprints (with lots and lots more coming *real soon*)
WHILE WE'RE AT ITFor the rest of this thread, I'm going to link to and single-tweet summarize some of the other recent @ONDRISTUDY papers and preprints (with lots and lots more coming *real soon*)
4/ An overview by Chris et al., on the neuroimaging/neuroinformatics infrastructure and pipelines: https://www.biorxiv.org/content/10.1101/2020.01.10.896415v1
4/ Here, Hassan provides background on the DTI QA/QC and pipelines: https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0226715
5/ Joel et al., cover the structural imaging pipeline (SABRE) which emphasizes the importance of vascular burdens & disease: https://www.biorxiv.org/content/10.1101/2019.12.13.875823v1.abstract
6/ @ADilliott et al., present a study on rare variants of NOTCH3 and white matter hyperintensities in Parkinson's: https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.28171
7/ Paula et al., provide a comprehensive overview of the QA/QC procedures for the neuropsych battery: https://journals.sagepub.com/doi/abs/10.1177/1073191120913933
8/ KB et al., show the fuzzy boundary of "cognitive impairment" in the MoCA for cerebrovascular disease: https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/methods-for-improving-screening-for-vascular-cognitive-impairment-using-the-montreal-cognitive-assessment/A14648B2FF0EA5BF30F87C6EE58F99B2
9/ Kelly tells us all about a secondary level of quality control & assurance in the @ONDRISTUDY project, where the neuroinformatics/biostatistics team provides multivariate outlier assessments: https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-019-0737-5
10/ Building on Kelly's work, I generalized some of those methods so we can look for multivariate outliers in categorical or mixed/heterogeneous data (e.g., continuous, ordinal, and categorical): https://www.biorxiv.org/content/10.1101/333005v3
11/ As a parallel to Kelly's ONDRI characteristics paper, I also led an all-hands team effort on caregiving burdens: https://psyarxiv.com/rxqev/
12/ Kapoor gives a breakdown of co-morbid pathology and screening in studies with an emphasis on Alzheimer's and the ONDRI study:
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad191097
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad191097
13/ @ADilliott provides a project-wide analysis of specific genetic markers and cognitive domains: https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/genetic-variation-in-the-ontario-neurodegenerative-disease-research-initiative/F26C090DF0F9EA2DB5E2709C1CCB1E72
end (for now!)/
I'm certainly missing some other recent @ONDRISTUDY papers/preprints sorry to my colleagues, collaborators, and friends if I did! So I'll just tag a bunch of people
@ADilliott @Raamana_ @MC_Tartaglia @DrRickSwartz @lcanresearch @breenneurology
I'm certainly missing some other recent @ONDRISTUDY papers/preprints sorry to my colleagues, collaborators, and friends if I did! So I'll just tag a bunch of people
@ADilliott @Raamana_ @MC_Tartaglia @DrRickSwartz @lcanresearch @breenneurology
