Thread by @ArumughamVinu, The allergic basis of #COVID19 severity explains why #Cetirizine/#Famotidine/#Vitamin C/ #Hydroxychloroquine (HCQ) [...]

The allergic basis of #COVID19 severity explains why #Cetirizine/ #Famotidine/ #Vitamin C/ #Hydroxychloroquine (HCQ) work. Allergies are caused by IgE antibodies against the allergens. IgE's natural role is defending against parasites (like malaria, hookworms).
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IgE on mast cells identify allergens. Histamine is released -> allergy symptoms including anaphylaxis. Proteins similar to #SARSCoV2 in vaccines caused the development of IgE that identify the virus - thus slow rolling #anaphylaxis upon infection.

https://doi.org/10.5281/zenodo.3748303
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Immunological mechanisms explaining the role of IgE, mast cells, histamine, elevating ferritin,...

A novel coronavirus, SARS-CoV-2 was identified in Wuhan, China. The disease caused by the virus can range in severity from asymptomatic to acute respiratory distress syndrome (ARDS) and death....

https://doi.org/10.5281/zenodo.3748303

Medications that reduce IgE levels (HCQ), block histamine (Cetirizine - histamine H1 blocker, Famotidine - histamine H2 blocker) or in the case of Vitamin C, metabolizing excess histamine, all therefore help in COVID-19.
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Since mechanisms are understood, these medicines can be used NOW. While clinical trials are good, they are not needed to SAVE LIVES NOW.

https://www.medrxiv.org/content/10.1101/2020.06.30.20137752v1
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Dual-Histamine Blockade with Cetirizine - Famotidine Reduces Pulmonary Symptoms in COVID-19 Patients

Background: The COVID-19 pandemic due to SARS-CoV-2 infection can produce Acute Respiratory Distress Syndrome as a result of a pulmonary cytokine storm. Antihistamines are safe and effective treatm...

https://www.medrxiv.org/content/10.1101/2020.06.30.20137752v1

https://gut.bmj.com/content/early/2020/06/10/gutjnl-2020-321852
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Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case...

Objective Treatment options for non-hospitalised patients with coronavirus disease 2019 (COVID-19) to reduce morbidity, mortality and spread of the disease are an urgent global need. The over-the-c...

https://gut.bmj.com/content/early/2020/06/10/gutjnl-2020-321852

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242191/
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Famotidine Use is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242191/

https://pubmed.ncbi.nlm.nih.gov/1578094/
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Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis - PubMed

Renewed interest in the antihistamine action of ascorbic acid has emerged with the recently recognized immunosuppressive role of histamine. We examined the antihistamine effect of acute and chronic...

https://pubmed.ncbi.nlm.nih.gov/1578094/

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik-Covid-Protocol-Summary.pdf
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HCQ reduces IgE and therefore helps in allergic asthma.

https://www.sciencedirect.com/science/article/abs/pii/S0091674998700867
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Hydroxychloroquine improves airflow and lowers circulating IgE levels in subjects with moderate...

Background Although antiinflammatory therapy is accepted as the cornerstone of asthma treatment, available systemic immunosuppressive agents are not w…

https://www.sciencedirect.com/science/article/abs/pii/S0091674998700867

High IgE levels make malaria worse explaining why HCQ helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534707/
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IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of...

In the course of studying immunoregulation in human Plasmodium falciparum malaria we have investigated IgE levels and IgE anti-plasmodial antibodies in children and adults from areas of high malaria...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534707/

High IgE levels make rheumatoid arthritis (RA) worse, explaining why HCQ helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905175/
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High IgE in rheumatoid arthritis (RA) patients is complexed with anti-IgE autoantibodies

This study presents data on more than 300 RA and allergic patients analysed for their serum levels of anti-immunoglobulin isotype autoantibodies and IgE. We observed high levels of IgE in sera of RA...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905175/

Same for Lupus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203948/
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Immunoglobulin E plays an immunoregulatory role in lupus

The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203948/

So HCQ helps in COVID-19, for the same reason it works in malaria, RA, lupus and asthma.

Mast cell stabilizers work at the root of the problem.

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
https://www.researchsquare.com/article/rs-30934/v2
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Repositioning Chromones for Early Anti-inflammatory Treatment of COVID-19

https://www.frontiersin.org/articles/10.3389/fphar.2020.00854/full
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Repositioning Chromones for Early Anti-inflammatory Treatment of COVID-19

The COVID-19 pandemic is posing an unprecedented sanitary threat. In the absence of specific vaccines and anti-SARS-CoV-2 drugs, medicines that may assist in tackling the emergency and limiting the...

https://www.frontiersin.org/articles/10.3389/fphar.2020.00854/full

Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy

https://pubmed.ncbi.nlm.nih.gov/32013309/
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Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy - PubMed

Coronavirus can cause respiratory syndrome which to date has affected about twelve thousand individuals, especially in China. Coronavirus is interspecies and can also be transmitted from man to man,...

https://pubmed.ncbi.nlm.nih.gov/32013309/

So mast cell stabilizers, cetirizine, famotidine, Vitamin C, HCQ can all be used IMMEDIATELY to help save lives NOW.

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