The allergic basis of #COVID19 severity explains why #Cetirizine/ #Famotidine/ #Vitamin C/ #Hydroxychloroquine (HCQ) work. Allergies are caused by IgE antibodies against the allergens. IgE's natural role is defending against parasites (like malaria, hookworms).
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IgE on mast cells identify allergens. Histamine is released -> allergy symptoms including anaphylaxis. Proteins similar to #SARSCoV2 in vaccines caused the development of IgE that identify the virus - thus slow rolling #anaphylaxis upon infection.
https://doi.org/10.5281/zenodo.3748303
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https://doi.org/10.5281/zenodo.3748303
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Medications that reduce IgE levels (HCQ), block histamine (Cetirizine - histamine H1 blocker, Famotidine - histamine H2 blocker) or in the case of Vitamin C, metabolizing excess histamine, all therefore help in COVID-19.
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Since mechanisms are understood, these medicines can be used NOW. While clinical trials are good, they are not needed to SAVE LIVES NOW.
https://www.medrxiv.org/content/10.1101/2020.06.30.20137752v1
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https://www.medrxiv.org/content/10.1101/2020.06.30.20137752v1
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HCQ reduces IgE and therefore helps in allergic asthma.
https://www.sciencedirect.com/science/article/abs/pii/S0091674998700867
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https://www.sciencedirect.com/science/article/abs/pii/S0091674998700867
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High IgE levels make malaria worse explaining why HCQ helps.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534707/
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534707/
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High IgE levels make rheumatoid arthritis (RA) worse, explaining why HCQ helps.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905175/
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905175/
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So HCQ helps in COVID-19, for the same reason it works in malaria, RA, lupus and asthma.
Mast cell stabilizers work at the root of the problem.
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
https://www.researchsquare.com/article/rs-30934/v2
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Mast cell stabilizers work at the root of the problem.
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
https://www.researchsquare.com/article/rs-30934/v2
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Repositioning Chromones for Early Anti-inflammatory Treatment of COVID-19
https://www.frontiersin.org/articles/10.3389/fphar.2020.00854/full
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https://www.frontiersin.org/articles/10.3389/fphar.2020.00854/full
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Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy
https://pubmed.ncbi.nlm.nih.gov/32013309/
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https://pubmed.ncbi.nlm.nih.gov/32013309/
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So mast cell stabilizers, cetirizine, famotidine, Vitamin C, HCQ can all be used IMMEDIATELY to help save lives NOW.