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DEBUNKING HYDROXYCHLOROQUINE (again)—w/ that viral HCQ video today, it’s time to bump up this thread 
on the mega RECOVERY randomized trial of HCQ with 4700 people showing NO benefit for mortality, & even higher risk of ventilator+mortality. And no subgroups benefit. #COVID19 https://twitter.com/DrEricDing/status/1283465624203788290
2) Trials are many fold stronger evidence than any Henry Ford retrospective analysis or case series report. Henry Ford Health system (thsr showed lower risk with HCQ) was also just one of several retrospective analyses. The other ones all showed NO BENEFIT or even HIGHER risk.
3) Moreover here is another RANDOMIZED trial of hydroxychloroquine done by @boulware_dr’s group in the US published in the NEJM showing no benefit for preventing #COVID19. https://twitter.com/drericding/status/1268309620944261122?s=21 https://twitter.com/DrEricDing/status/1268309620944261122
4) here is another earlier HCQ retrospective analysis of 1400 patients in 25 NYC hospitals. Again, no benefit for either HCQ or HCQ+azithromycin sliced 12 different ways. https://twitter.com/drericding/status/1259978756409696257?s=21 https://twitter.com/drericding/status/1259978756409696257
5) I prefer if HCQ stays in the dustbin or debunked stuff. But why am I posted all these older HCQ studies? Because the HCQ misinformation video has been seen over 14 mil times already. I’m not linking it cuz it’s crap. But here is summary. https://twitter.com/kevinroose/status/1287906751069581318?s=21 https://twitter.com/kevinroose/status/1287906751069581318
6) And another May study of #Hydroxychloroquine from New York City in NEJM: from 1376 patients over 22 days, there was NO association between hydroxychloroquine and intubation or death (hazard ratio, 1.04, 95% CI, 0.82 to 1.32). Results robust. https://www.nejm.org/doi/full/10.1056/NEJMoa2012410
7) And another hydroxychloroquine study in CRITICAL CARE journal- of 80 patients, was:
no difference in ventilator-free days at day 28
No diff in mortality at day 14 & day 28.
no difference in viral load between day 0 and day 7.
NOTHING. https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03117-9
no difference in ventilator-free days at day 28No diff in mortality at day 14 & day 28. no difference in viral load between day 0 and day 7. NOTHING. https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03117-9
8) For those just arriving here from another tweet thread, note that this trial by Boulware in NEJM was for HCQ and PREVENTION... not for hospitalized, yet still no effect. Reposting from above so bottom/mid-thread arrivers see it: https://twitter.com/drericding/status/1268309620944261122?s=21 https://twitter.com/drericding/status/1268309620944261122
9) For prevention (prophylaxis), another experiment in macaque monkeys also did not show benefit for either HCQ or HCQ+azithrymycin combo on viral load or prevention. https://twitter.com/flahault/status/1286069693439254529?s=21 https://twitter.com/flahault/status/1286069693439254529
10) At the end of the day, folks on twitter should not be arbiter. Just wish there was some group of experts who take a look at all HCQ data instead of online pundits... (checks notes)... oh wait, the @US_FDA... (checks notes again)... and it’s dangerous. https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or
11) Connecting my two threads in HCQ together—my other thread discusses what proponents of HCQ demand in terms of evidence. Basically, HCQ proponents want nothing less than a trial for HCQ+azithro+zinc among non-hospitalized #COVID19 patients or bust! https://twitter.com/drericding/status/1288142332219596800?s=21 https://twitter.com/drericding/status/1288142332219596800
