Time to start a new thread, because the first one is getting unweildly. Prior articles documenting possible #SARSCoV2 #Reinfection or #Reactivation here: https://twitter.com/PRussW1/status/1273476315811897350?s=20
I suspect this narrative is going to start picking up steam leading into the next 2-3 months. Time will tell. #SARS
#Reinfection/ #Reactivation. https://twitter.com/lerpierre/status/1285909948044541953?s=20
#Reinfection/ #Reactivation. https://twitter.com/lerpierre/status/1285909948044541953?s=20
Can you get coronavirus twice? [Experts] skeptical, even as anecdotal reports mount (Note: this is the problem). H/t
@adamhamdy https://www.washingtonpost.com/health/2020/07/22/can-you-get-coronavirus-twice/
@adamhamdy https://www.washingtonpost.com/health/2020/07/22/can-you-get-coronavirus-twice/
A team of researchers published a theory in BMG Global Health that suggests antibodies could [cause] Antibody-Dependent-Enhancement that can actually lead to severe [ #SARSCoV2] [ #Reinfection] cases. https://bgr.com/2020/07/23/antibodies-might-also-fuel-coronavirus-reinfection-says-a-puzzling-theory-5858506/
Another article discussing the possibility of antibodies inducing ADE in a #SARSCov2 #Reinfection. https://www.sciencesetavenir.fr/sante/covid-19-les-formes-graves-pourraient-provenir-d-une-deuxieme-infection_146152
#Covid #Reinfection? Itâs Very Unlikely, Experts Say https://www.nytimes.com/2020/07/22/health/covid-antibodies-herd-immunity.html
#Covid #Reinfection: Doctors unsure amid rise in reports of people falling sick again
https://www.medihelpweb.com/covid-19-reinfection-doctors-unsure-amid-rise-in-reports-of-people-falling-sick-again/?feed_id=56764&_unique_id=5f19a000b8a98
https://www.medihelpweb.com/covid-19-reinfection-doctors-unsure-amid-rise-in-reports-of-people-falling-sick-again/?feed_id=56764&_unique_id=5f19a000b8a98
I hope the scientific community eventually gets around to confirming or disproving whether people are experiencing #Reinfections to #SARSCoV2/ #Covid. If yes, what is the population risk.
https://twitter.com/outfrontcnn/status/1286814293896372227?s=21 https://twitter.com/OutFrontCNN/status/1286814293896372227
https://twitter.com/outfrontcnn/status/1286814293896372227?s=21 https://twitter.com/OutFrontCNN/status/1286814293896372227
I know, there are no confirmed cases of #Reinfection to #SARSCoV2/ #Covid. Nevertheless...
H/t @adamhamdy
https://twitter.com/beanietoddps/status/1287499709767016449?s=21 https://twitter.com/BeanieToddPS/status/1287499709767016449
H/t @adamhamdy
https://twitter.com/beanietoddps/status/1287499709767016449?s=21 https://twitter.com/BeanieToddPS/status/1287499709767016449
#Reinfection to #SARSCoV2/ #Covid? Sure would be useful if studies were done in this space to prove or disprove. H/t @adamhamdy
https://twitter.com/aliostad/status/1287837025241112580?s=21 https://twitter.com/aliostad/status/1287837025241112580
https://twitter.com/aliostad/status/1287837025241112580?s=21 https://twitter.com/aliostad/status/1287837025241112580
As was suggested to me by someone else, keep an eye on Iran re: #Reinfection #SARSCoV2
https://twitter.com/aliostad/status/1287659186554314753?s=21 https://twitter.com/aliostad/status/1287659186554314753
https://twitter.com/aliostad/status/1287659186554314753?s=21 https://twitter.com/aliostad/status/1287659186554314753
H/t @adamhamdy
Iran appears to be the only country making a concerted effort to assess #SARS2 #Reinfection. They are suggesting it is happening. They seem to be unclear on whether it is a product of mutation or more general immune response decline.
https://twitter.com/aliostad/status/1288143213568708608?s=21 https://twitter.com/aliostad/status/1288143213568708608
Iran appears to be the only country making a concerted effort to assess #SARS2 #Reinfection. They are suggesting it is happening. They seem to be unclear on whether it is a product of mutation or more general immune response decline.
https://twitter.com/aliostad/status/1288143213568708608?s=21 https://twitter.com/aliostad/status/1288143213568708608
The developing story in Iran May prove informative on the potential #SARSCov2 #Reinfection narrative. May be worth keeping an eye on.
https://twitter.com/isna_farsi/status/1288539172064681984?s=21 https://twitter.com/isna_farsi/status/1288539172064681984
https://twitter.com/isna_farsi/status/1288539172064681984?s=21 https://twitter.com/isna_farsi/status/1288539172064681984
Is this a #SARSCoV2 #Reinfection? If yes, how representative are cases like this?
https://twitter.com/aliostad/status/1289108726511738880?s=21 https://twitter.com/aliostad/status/1289108726511738880
https://twitter.com/aliostad/status/1289108726511738880?s=21 https://twitter.com/aliostad/status/1289108726511738880
I get that only the really bad anecdotes of potential #Reinfection of #SARSCoV2 might get reported. Again, when will we study #Reinfections in earnest and, if it is a phenomena we have to deal with in the shorter term, what are the population level risks?
https://twitter.com/aaron_derfel/status/1289036558016950272?s=21 https://twitter.com/Aaron_Derfel/status/1289036558016950272
https://twitter.com/aaron_derfel/status/1289036558016950272?s=21 https://twitter.com/Aaron_Derfel/status/1289036558016950272
Thus, for persons recovered from SARS-CoV-2 infection, a positive PCR during the 90 days after illness onset more likely represents persistent shedding of viral RNA than reinfection. So >90 days could mean reinfection? Another tone change?
https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html#:~:text=Persons%20infected%20with%20related%20endemic,days%20after%20onset%20of%20infection.
https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html#:~:text=Persons%20infected%20with%20related%20endemic,days%20after%20onset%20of%20infection.
Continuing on, "the symptoms they experienced were not the same the second time". H/t @adamhamdy
https://www.facebook.com/LaCrosseCountyHealthDepartment/posts/3120484674687218
https://www.facebook.com/LaCrosseCountyHealthDepartment/posts/3120484674687218
Is this #LongCovid, #Reactivation, #Reinfection to #SARSCov2? https://brazilian.report/coronavirus-brazil-live-blog/2020/08/06/brazilian-study-suggests-covid-19-reinfection-is-possible/
H/t @adamhamdy. More on this strange case. Seems like it may be more of a case of longer lasting latent infection to #SARSCov2, than actual #Reinfection, but who knows. https://www1.folha.uol.com.br/equilibrioesaude/2020/08/pesquisadores-da-usp-ribeirao-relatam-reinfeccao-de-paciente-recuperada-de-covid-19.shtml
Are these #Covid #Reinfection cases or just #LongCovid. If I had to hazard a guess some of the cases could be either. https://m.mid-day.com/articles/second-time-unlucky-did-our-battle-with-covid-19-just-get-longer/22924230
âPeople might think they can't transmit it anymore if they've already had it and those people should still use face masks, social distancing and hand hygiene because we just don't know.â
Is this really what we are trying to avoid/ignore? https://wxow.com/2020/08/08/health-dept-waiting-to-address-covid-19-positive-re-infection-case/
Is this really what we are trying to avoid/ignore? https://wxow.com/2020/08/08/health-dept-waiting-to-address-covid-19-positive-re-infection-case/
H/t @adamhamdy
Is this a #Reinfection case? #Reactivation or #LongCovid? Definitely need to start looking into these cases. Open question, would celiac disease create an autoimmune distinction that could precipitate reinfection or reactivation? https://6abc.com/covid-19-covid-reinfection-coronavirus-can-you-get-twice/6358182/
Is this a #Reinfection case? #Reactivation or #LongCovid? Definitely need to start looking into these cases. Open question, would celiac disease create an autoimmune distinction that could precipitate reinfection or reactivation? https://6abc.com/covid-19-covid-reinfection-coronavirus-can-you-get-twice/6358182/
Iâve previously suggested that we need to keep an eye on Iran re: #reinfection & #reactivation. Very curious as to what is going on in Iran that driving this article.
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C4A2A602F96D6E1B3352BF91A6E427E5/S1935789320002748a.pdf/with_risk_of_reinfection_is_covid19_here_to_stay.pdf
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C4A2A602F96D6E1B3352BF91A6E427E5/S1935789320002748a.pdf/with_risk_of_reinfection_is_covid19_here_to_stay.pdf
https://twitter.com/adamhamdy/status/1293457979224850432?s=21 https://twitter.com/adamhamdy/status/1293457979224850432
Clinical findings always lead scientific determinations. By no means conclusive, but certainly interesting. #SARSCoV2 #Covid #Reinfection
https://twitter.com/gloangiemd/status/1293529186431311874?s=21 https://twitter.com/gloangiemd/status/1293529186431311874
https://twitter.com/gloangiemd/status/1293529186431311874?s=21 https://twitter.com/gloangiemd/status/1293529186431311874
Three potential #Covid #SARSCoV2 #Reinfection cases in Cambodia. H/t @adamhamdy https://cambodianess.com/article/two-new-covid-19-cases-found-as-confusion-mounts-over-reinfection
Another examplr of alleged clinical findings of potential #Reinfection related to #SARSCoV2/ #Covid
https://twitter.com/berryaneurysm/status/1293600047557476356?s=21 https://twitter.com/BerryAneurysm/status/1293600047557476356
https://twitter.com/berryaneurysm/status/1293600047557476356?s=21 https://twitter.com/BerryAneurysm/status/1293600047557476356
While I get that gold plated research standards were not used, clinical findings continue to diverge from consensus hypotheses regarding #SARSCoV2 #Covid #reinfection.
https://twitter.com/adamhamdy/status/1293909769493680137?s=21 https://twitter.com/adamhamdy/status/1293909769493680137
https://twitter.com/adamhamdy/status/1293909769493680137?s=21 https://twitter.com/adamhamdy/status/1293909769493680137
H/t @adamhamdy Two patients in China demonstrating possible #SARSCoV2 #Covid #Reinfection or #Reactivation https://www.bloomberg.com/news/articles/2020-08-13/two-chinese-patients-test-positive-months-after-virus-recovery
A relevant take on the reinfection debate. Highlights the weakness in the current hyper-conservative scientific approach & the possible ramifications of our collective failure to deal with concepts that, if proved, could have an immense human impact.
https://twitter.com/adamhamdy/status/1294035753169756163?s=21 https://twitter.com/adamhamdy/status/1294035753169756163
https://twitter.com/adamhamdy/status/1294035753169756163?s=21 https://twitter.com/adamhamdy/status/1294035753169756163
Long story short, severe #Covid likely leads to T cell exhaustion. It is potential T-cell exhaustion that is the fly on the ointment for t-cell immunity, as well as a real risk for #LongCovid. This should be a warning sign. https://www.medrxiv.org/content/10.1101/2020.08.10.20171371v1
So #SARSCov2 has open and closed formations.
"These results suggest that the natural prefusion state occludes neutralising RBD epitopes, achieving
conformational shielding from antibodies." https://www.biorxiv.org/content/10.1101/2020.08.13.249177v1
"These results suggest that the natural prefusion state occludes neutralising RBD epitopes, achieving
conformational shielding from antibodies." https://www.biorxiv.org/content/10.1101/2020.08.13.249177v1
"These data, together with the recent observation of a similar structure in wild-type Spike ectodomain strongly suggest that before recognition by a cellular receptor, the âlockedâ conformation will be the predominant prefusion form on the viral surface.
So the latest CDC guidance is that we have is a 3 month window of immune protection. What does that means for #Reinfection for #SARSCoV2/ #Covid? And what are the implications for vaccine development? https://thehill.com/policy/healthcare/512090-cdc-gives-three-month-window-of-immunity-after-covid-infection
Here is the actual CDC guidance on the three month #SARSCoV2/ #Covid #Immunity that we can reasonably rely on. This should shock exactly nobody who has been paying attention. https://www.cdc.gov/coronavirus/2019-ncov/if-you-are-sick/quarantine.html
The key point is that the immune system is suppressed quickly during the acute phase of infection. This allows the virus to establish productive infection efficiently, to avoid symptom-based quarantine, such as fever, and to spread more effectively. https://www.thestreet.com/latest-news/covid-19-may-sabotage-immune-system-say-researchers
While some groups console themselves with the notions that âthere are no confirmed cases of reinfection or reactivationâ, other groups are taking lead and starting research into an important question.
https://twitter.com/adamhamdy/status/1295089057035366402?s=21 https://twitter.com/adamhamdy/status/1295089057035366402
https://twitter.com/adamhamdy/status/1295089057035366402?s=21 https://twitter.com/adamhamdy/status/1295089057035366402
Interestingly, the majority of individuals have low neutralization capacity and only 6% of the healthcare workers showed high neutralizing titers against both authentic SARS-CoV-2 virus and the pseudotyped virus. https://biorxiv.org/cgi/content/short/2020.08.15.252353v1
H/t @adamhamdy
https://twitter.com/nanogenomic/status/1295429314620530688?s=21 https://twitter.com/nanogenomic/status/1295429314620530688
https://twitter.com/nanogenomic/status/1295429314620530688?s=21 https://twitter.com/nanogenomic/status/1295429314620530688
https://twitter.com/nanogenomic/status/1295448888812244992?s=21 https://twitter.com/nanogenomic/status/1295448888812244992
First case of #SARSCoV2/ #Covid #Reinfection in a policy official? https://www.philstar.com/headlines/2020/08/18/2036079/doh-studying-aos-virus-reinfection
H/t @adamhamdy
If this is a #SARSCoV2/ #Covid #reinfection, at least it was milder than the initial infection. https://www.thestandard.com.hk/breaking-news/section/4/153334/Man-cleared-of-virus-reinfected-and-not-showing-symptoms
If this is a #SARSCoV2/ #Covid #reinfection, at least it was milder than the initial infection. https://www.thestandard.com.hk/breaking-news/section/4/153334/Man-cleared-of-virus-reinfected-and-not-showing-symptoms
Weaker anecdote of possible #Reinfection but reporting nonetheless. https://www.outlookindia.com/newsscroll/some-delhi-hospitals-seeing-covid-reemergence-in-recovered-patients/1917421
Two of the adults involved, clearly seem to be cases of reinfection,â the memo reads. âHopefully their illness will be light, but the possibility now exists [for reinfection]â.
H/t @adamhamdy https://crownheights.info/chabad-news/712279/mountain-lodge-estates-under-lockdown-as-isolated-covid-case-causes-mini-outbreak/
H/t @adamhamdy https://crownheights.info/chabad-news/712279/mountain-lodge-estates-under-lockdown-as-isolated-covid-case-causes-mini-outbreak/
https://twitter.com/daltmann10/status/1296365731148431362?s=21 https://twitter.com/Daltmann10/status/1296365731148431362
âBoth had antibodies but upon recent retesting had âlostâ their antibodies, and now, after being exposed to Covid, these people became sick again and tested positiveâ.
Are these #Covid #Reinfections? https://www.timesofisrael.com/new-covid-19-cases-among-us-orthodox-may-preclude-opening-school-year-say-mds/
Are these #Covid #Reinfections? https://www.timesofisrael.com/new-covid-19-cases-among-us-orthodox-may-preclude-opening-school-year-say-mds/
First confirmed #SARSCoV2 #Covid #Reinfection case. Time to start moving some goalposts. https://twitter.com/cwylilian/status/1297830744509698050
I really debated tweeting this one (given how tragic this is), but given the lack of credence by âexpertsâ regarding possible risks of #SARSCoV2/ #Covid #Reinfection I have reluctantly decided to add this one here. Hopefully, we can begin to take this risk more seriously https://twitter.com/penmanila/status/1297358850996092930
More discussion of the confirmed case of #Covid #Reinfection from Hong Kong https://twitter.com/bbcworld/status/1297932156891803650
Two more confirmed cases of #SARSCoV2/ #Covid #Reinfection? https://www.nbcnews.com/news/world/cases-covid-19-reinfection-netherlands-belgium-national-broadcaster-reports-n1237985
Article 2 on two more confirmed Covid reinfection in Holland and Belgium. https://www.businessinsider.com/2-new-coronavirus-reinfection-cases-belgium-netherlands-hong-kong-2020-8
Hong Kong paper discussing the first *confirmed* case of #SARSCoV2/ #Covid Reinfection. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1275/5897019#.X0UzD2qd1yI.twitter
Possible #Covid #Reinfection case in Russia. https://www.themoscowtimes.com/2020/08/26/siberian-governor-reinfected-with-coronavirus-a71252
Two more potential #Covid #Reinfections in India. https://www.timesnownews.com/hyderabad/article/hyderabad-telangana-to-investigate-two-possible-cases-of-covid-19-reinfection/642884
Mutations and non-durable immune responses. The primary drivers of #Covid #Reinfections https://www.globaltimes.cn/content/1198975.shtml
Another confirmed case of #Covid #Reinfection, this time in the United States.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3681489
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3681489
Four more confirmed cases of #Covid #Reinfection in Holland. https://www.businessinsider.com/four-coronavirus-reinfection-cases-reported-in-the-netherlands-2020-8
More detail on the form of cardiac damage that #Covid can cause. What effect on the
(in aggregate and in the long run) from possible repeat infections? Hopefully not severe. What effect on life expectancy? Note this appears to be a feature regardless of disease severity. https://twitter.com/erictopol/status/1299027542272172032

Some commentary on the confirmed #SARSCov2 #Reinfection I posted yesterday, for the patient from Nevada, USA who presented with more severe symptoms upon reinfection. https://twitter.com/virusesimmunity/status/1299342270177726464
Confirmed case of #SARSCoV2/ #Covid #Reinfection in Ecuador. Second infection more severe than the first. https://twitter.com/BNODesk/status/1300179554905075715?s=20
#Covid #Reinfection in the UK https://www.thesun.co.uk/news/12567441/care-worker-coronavirus-twice-beat-it/
Another #Covid #Reinfection case, this time in India. https://m.timesofindia.com/city/mumbai/doctor-is-mumbais-first-recorded-case-of-covid-reinfection/articleshow/77922100.cms
A new sero-survey conducted by the Gujaratâs Ahmedabad Municipal Corporation (AMC) has revealed that 40 per cent of patients who recovered from Covid-19 did not have the antibodies three months after they were infected. https://www.dailypioneer.com/2020/page1/40--lost-antibody-three-months-after-recovery----reinfection-risk-high.html
An additional four (suspected) cases of #Covid #Reinfection in India. https://www.financialexpress.com/lifestyle/health/mumbai-four-resident-doctors-suspected-to-be-reinfected-by-covid/2075218/
Sick for a third time in 4 months, and hospitalized?!?!? https://twitter.com/kathiebennett/status/1302337930384596995
Seven (7) cases of possible reinfection being investigated in a hospital in Brazil. https://paranaportal.uol.com.br/cidades/coronavirus-reinfeccao-parana/
It appears I previously posted a dead link to the paper discussing the confirmed #Covid #Reinfection case in Reno. Re-posted as a correction.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3680955
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3680955
Confirmed case of #Covid #Reinfection in Brazil. With reinfection presenting more severely than initial infection, and requiring hospitalization. https://afnoticias.com.br/estado/tocantins-registra-1o-caso-de-reinfeccao-pela-covid-19-paciente-teve-a-doenca-em-junho
Three cases of reinfection in Thailand? If yes, at least they are seemingly symptomatic. https://www.thephuketnews.com/alarm-as-three-of-six-new-covid-cases-reinfected-77228.php
An (unconfirmed) reinfection case from Chennai, India.
âHe had tested positive in May, and had recovered. Now, he has tested positive again and is in the ICU of the hospital,â the doctor said. https://www.newindianexpress.com/cities/chennai/2020/sep/08/reinfection-of-government-doctor-from-chennai-sparks-concern-2193910.html
âHe had tested positive in May, and had recovered. Now, he has tested positive again and is in the ICU of the hospital,â the doctor said. https://www.newindianexpress.com/cities/chennai/2020/sep/08/reinfection-of-government-doctor-from-chennai-sparks-concern-2193910.html
First potential case of #Covid #Reinfection in Canada (Nova Scotia). I am concerned that the official narrative that reinfections are rare is risky, since we may very well be at the leading edge of the curve for reinfection cases.
https://globalnews.ca/news/7324366/covid-19-reinfection-canada/amp/#click=https://t.co/ATloUFOxn6
https://globalnews.ca/news/7324366/covid-19-reinfection-canada/amp/#click=https://t.co/ATloUFOxn6
Four more reinfection cases (this time in Spain. Three are mild cases of reinfection. One required hospitalization (time interval of 5 months). Herd immunity, how? https://twitter.com/itosettiMD_MBA/status/1305502379350151174
Following from 1 of the 4 reinfections in Spain. Mild infection â-> Requiring intubation upon reinfection. Making assumptions about Covid IS dangerous, despite what anyone might think or say. https://metro.co.uk/2020/09/15/doctor-put-on-ventilator-after-being-reinfected-as-spain-braces-for-second-wave-13273989/
There are likely many more than three (3), but I am certainly glad to see the scientific community coming around. Though all of this has been obvious for months and a possible concern since, at least, March. https://twitter.com/DrEricDing/status/1308424370008797184
Reposting this #Covid #Reinfection tracker.
Frankly, reinfections are not being assessed in nearly a robust enough fashion. My personal theory is that there are many many more reinfections that are going undocumented dude to lack of investigation. https://bnonews.com/index.php/2020/08/covid-19-reinfection-tracker/
Frankly, reinfections are not being assessed in nearly a robust enough fashion. My personal theory is that there are many many more reinfections that are going undocumented dude to lack of investigation. https://bnonews.com/index.php/2020/08/covid-19-reinfection-tracker/
Reinfection out of Barcelona, Spain. https://twitter.com/itosettiMD_MBA/status/1308730539139047424
Whole Genome Sequencing Confirmed SARS-CoV-2 Reinfections Among Healthcare Workers in India with Increased Severity in the Second Episode
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3688220
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3688220
Two #Covid #Reinfections in Thailand. https://www.nationthailand.com/news/30395112?utm_source=homepage&utm_medium=internal_referral
#Covid #Reinfection in New Jersey, USA https://www.myjournalcourier.com/news/article/Cass-reports-reinfection-another-death-in-Jersey-15593202.php
"Taken together, these findings suggest that poorly
developed or waned antibodies against the D614 virus formed after primary infection in
March were not protective against reinfection with the D614G spike variant acquired in
July." https://www.medrxiv.org/content/10.1101/2020.09.22.20192443v1
developed or waned antibodies against the D614 virus formed after primary infection in
March were not protective against reinfection with the D614G spike variant acquired in
July." https://www.medrxiv.org/content/10.1101/2020.09.22.20192443v1
This is why reinfection is a serious threat. Could be a nightmarish scenario... https://twitter.com/DrDenaGrayson/status/1310935949568860160?s=20
The trend of #Covid science in a general (and reinfection in particular). Prove it wrong! https://twitter.com/adamhamdy/status/1311069945569128452?s=20
Antibodies disappearing in 60 days? Who could have foreseen that? 

PS - Letâs talk about what that may mean for vaccine development. https://www.fox17online.com/news/national/coronavirus/covid-19-antibodies-are-disappearing-faster-than-we-first-thought


PS - Letâs talk about what that may mean for vaccine development. https://www.fox17online.com/news/national/coronavirus/covid-19-antibodies-are-disappearing-faster-than-we-first-thought
People reinfected with Covid can spread it to other. Hardly surprising, but an important finding nonetheless. http://newsonair.com/Main-News-Details.aspx?id=401106
#Covid #Reinfections are rare? We may want to begin reconsidering that position. https://twitter.com/devisridhar/status/1315904242612346886
102 cases of #Covid #Reinfection??? Becoming increasingly less rare. https://twitter.com/laughingginge/status/1315918691670855685