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We are sure, you have wondered at least one time, what happens with Immune macroenvironment during #Cancer development. So let us tell you a fantastic story, where #dimensionalityreduction #techniques had let us meet the big picture of cancer in the systemic context [1/10].
Some studies suggest that systemic #ImmuneSystem changes occur with cancer, but, until now the dynamicity of the Immune system during tumor burden has been poorly characterized [2/10].
Recently, Allen, a work done by @SpitzerLab showed that tumors drove dynamic shifts over the time in the organization and function of immune cells across the organism [3/10].
Through #singlecell analysis, they characterize the systemic Immune landscape in eight mouse tumor models [4/10].
![Through #singlecell analysis, they characterize the systemic Immune landscape in eight mouse tumor models [4/10].](https://pbs.twimg.com/media/EdBq2LIU0AEaVlc.png "Through #singlecell analysis, they characterize the systemic Immune landscape in eight mouse tumor models [4/10].")
They found that three distinct breast #cancer models converged on similar systemic changes [5/10].
![They found that three distinct breast #cancer models converged on similar systemic changes [5/10].](https://pbs.twimg.com/media/EdBrE3JVcAAxlv-.png "They found that three distinct breast #cancer models converged on similar systemic changes [5/10].")
Also, when analyzing the #Immune organs during tumor growth, they observed that T cell subsets were altered across tissues between early and late disease timepoints [6/10].
![Also, when analyzing the #Immune organs during tumor growth, they observed that T cell subsets were altered across tissues between early and late disease timepoints [6/10].](https://pbs.twimg.com/media/EdBrXipVcAEhune.png "Also, when analyzing the #Immune organs during tumor growth, they observed that T cell subsets were altered across tissues between early and late disease timepoints [6/10].")
Importantly, these changes result in attenuated responses to new Immune challenges [7/10].
Strikingly, tumor resection was enough to revert the systemic Immune landscape [8/10].
Thus, these findings not only amply our understanding of tumor macroenvironment, but also could be valuable to designed anti-tumor immune responses and clinical trials in the future [9/10].
If you are interested in getting more details on this research, do not miss this chance!
Join us this Sat on the next session of @publicjournalclub hosted by @extended_gene to discuss directly with @ballen1725 and @InflammatoryDC, the first authors of this work [10/10].
![If you are interested in getting more details on this research, do not miss this chance! Join us this Sat on the next session of @publicjournalclub hosted by @extended_gene to discuss directly with @ballen1725 and @InflammatoryDC, the first authors of this work [10/10].](https://pbs.twimg.com/media/EdBstPXUwAEZ4jz.png "If you are interested in getting more details on this research, do not miss this chance! Join us this Sat on the next session of @publicjournalclub hosted by @extended_gene to discuss directly with @ballen1725 and @InflammatoryDC, the first authors of this work [10/10].")
Join us this Sat on the next session of @publicjournalclub hosted by @extended_gene to discuss directly with @ballen1725 and @InflammatoryDC, the first authors of this work [10/10].
All the credits of this thread to @victornieto member of @publicjournalc, who recently won 1st T-Bio Online Biology Tournament.
Congratulations on all your achievements Vic! You are an inspiration to all of us :).
Felicidades!
Congratulations on all your achievements Vic! You are an inspiration to all of us :).
Felicidades!
