Our paper about #SARSCoV2-specific #tcell immunity in cases of #COVID19 and #SARS, and uninfected controls is now out, peer-reviewed and published in @nature! https://www.nature.com/articles/s41586-020-2550-z
3">https://www.nature.com/articles/... take-home messages:
(1/5)
3">https://www.nature.com/articles/... take-home messages:
(1/5)
1) Infection with #SARSCoV2 induces virus-specific T cells
2) Patients recovered from #SARS 17 years ago still possess virus-specific memory T cells displaying cross-reactivity to #SARSCoV2
(2/5)
2) Patients recovered from #SARS 17 years ago still possess virus-specific memory T cells displaying cross-reactivity to #SARSCoV2
(2/5)
3) Over 50% of donors with no infection or contact with SARSCoV1/2 harbor expandable T cells cross-reactive to #SARSCoV2 likely induced by contact or infection with other #coronavirus strains
(3/5)
(3/5)
They key question: Do these T cells protect from severe #COVID19 ?
The short answer: We don’t know yet…however, indications that pre-existing cross-reactive T cells can be beneficial were reported for influenza H1N1…let’s study if this is also the case for #COVID-19.
(4/5)
The short answer: We don’t know yet…however, indications that pre-existing cross-reactive T cells can be beneficial were reported for influenza H1N1…let’s study if this is also the case for #COVID-19.
(4/5)
We find #SARS-specific T cells 17 years post infection - potentially really good news for long-term immunity and #vaccine development.
Fantastic team work, big thanks to all our co-authors @dukenus @NUSingapore @NUSMedicine @SingHealthSG @astar_research
(5/5)
Fantastic team work, big thanks to all our co-authors @dukenus @NUSingapore @NUSMedicine @SingHealthSG @astar_research
(5/5)