Julia Louis-Dreyfus managed to create too pop-culturally significant, iconic characters on television w/Elaine (Seinfeld) and Selina Meyer (VEEP). That's an incredible feat. Who are some others who have done this?

I’m loving y’alls responses! All deserving of recognition and celebration! It’s so hard to move beyond typecasting and lightning rarely strikes twice. Thanks for everyone chiming in! She’s pretty cusp-y I think, ya?

just got back from a walk and thought about some others that are either definitely iconic or close.
Kerri Russell as Felicity & Elizabeth Jennings are definites.

Edie Falco as Carmela Soprano & Nurse Jackie

2 personally iconic characters....
Carrie Coon as Gloria Burgle & Nora Durst

and I would only consider one of these iconic, but since I'm currently watching Six Feet Under....
Michael C. Hall as Dave Fisher & Dexter