While I commend them for this work, a few things jump out at me right away looking at the data tables. The sample of the patients was heavily skewed towards a few demographics. 1/ https://twitter.com/BrennanSpiegel/status/1280527527325265920">https://twitter.com/BrennanSp...

74.5% of the COVID-19 patients were 30-39 yo (27.1% in the control group). 69.7% were Latinx (15.3% in control). 73.1% smoke every day (22.5% in control). 2/

But here& #39;s where I raise an eyebrow. 69.6% of the COVID-19 patients had a high school education or less (28.7% in control), but 63.5% of the COVID-19 made 200k+ per year (7.4% in the control group). Ultra-wealthy non-college 30-39yos, who mostly smoke. Huh? 3/

I& #39;m not sure how with that data sampling, you can pick out PPIs as the culprit, regardless of what regression you do. We& #39;re going to need far better evidence than this before we throw PPIs under the bus yet again based on an observational study.