1/ @VirusesImmunity men were found to have higher initial immune response & females with higher immune cytokine levels had worse disease. Could these pts potentially have a stronger autoimmune response, and subsequent extent of viral infection? #COVIDー19 https://www.medrxiv.org/content/10.1101/2020.06.06.20123414v2">https://www.medrxiv.org/content/1... https://twitter.com/EricTopol/status/1279891795262857216">https://twitter.com/EricTopol...

2/ @VirusesImmunity interestingly, excessive immune response was suggested by Li et al after finding a positive correlation between ACE2 expression and immune signatures for men and older persons. https://idpjournal.biomedcentral.com/articles/10.1186/s40249-020-00662-x">https://idpjournal.biomedcentral.com/articles/... #COVIDー19

3/ @VirusesImmunity one of the very interesting findings in your talk was the persistence of viral load in severe disease, driving the immune response...which makes me question the potential role of viral replication in immuno-privileged organs #COVIDー19 https://www.medrxiv.org/content/10.1101/2020.06.23.20138289v3">https://www.medrxiv.org/content/1...

?Virus is initially able to evade the immune system, but when is finally detected, it mimics host structures, so that the antibodies that are developed also attack those host structures. Host structures likely higher in number than the virus --> autoimmune response --> https://abs.twimg.com/emoji/v2/... draggable="false" alt="🦠" title="Microbe" aria-label="Emoji: Microbe"> spreads