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Many new studies suggest that one of the fundamental assumptions about COVID that 𝙚𝙫𝙚𝙧𝙮𝙤𝙣𝙚 is susceptible, may be wrong.
CAUTION: However, this doesn’t mean that we relax any precautions, coz the % of population susceptible is very high, & COVID is deadly.
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CAUTION: However, this doesn’t mean that we relax any precautions, coz the % of population susceptible is very high, & COVID is deadly.
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Study in @CellPressNews found 70-100% of people recovering from COVID have good T cell immune responses targeting the spike protein & other viral proteins. But they also found 40–60% of people who never had COVID also had T cells reactive to SARS-CoV2. https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3
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For the group they considered unexposed to COVID they used cells collected in 2015-2018. So no chance of exposure to COVID.
These findings suggest that immune responses we generate to common corona viruses (~20% of common cold) may be cross reactive & protect against COVID.
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These findings suggest that immune responses we generate to common corona viruses (~20% of common cold) may be cross reactive & protect against COVID.
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I heard from a person present at a meeting yesterday, that Dr. Fauci acknowledged that this finding of cross immunity from T cell mediated responses to prior corona virus infections is indeed possible. Which brings hope, but we need to learn a lot more.
@ASlavitt
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@ASlavitt
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We don’t know if the T cell mediated responses against COVID in the Cell paper in unexposed people is protective. But based on SARS animal studies & data that in H1N1 presence of cross reactive cells led to less severe infections, the authors hope that this can be protective.
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There are other pieces of supportive data. Here is one.
6/ https://immunology.sciencemag.org/content/5/48/eabd2071
6/ https://immunology.sciencemag.org/content/5/48/eabd2071
Here is another.
7/ https://news.ki.se/immunity-to-covid-19-is-probably-higher-than-tests-have-shown
7/ https://news.ki.se/immunity-to-covid-19-is-probably-higher-than-tests-have-shown
I’ve pointed out earlier reasons to think this is the case based on what happened in Wuhan, Lombardy, and NY.
8/ https://twitter.com/VincentRK/status/1274792133929639936
8/ https://twitter.com/VincentRK/status/1274792133929639936
But a great thread explaining susceptibility is one that was posted by @Rfonsi1 yesterday.
Check it out.
9/ https://twitter.com/Rfonsi1/status/1277643561316388864
Check it out.
9/ https://twitter.com/Rfonsi1/status/1277643561316388864
This is quite amazing. @vmontori @Rfonsi1 @DrSidMukherjee
@vmontori had previously hinted that overall Peru has major drop in COVID despite no change in behavior. https://twitter.com/julefranve/status/1275070033383702535
@vmontori had previously hinted that overall Peru has major drop in COVID despite no change in behavior. https://twitter.com/julefranve/status/1275070033383702535
Link to earlier thread on how the natural history in hotspots may shed some light on susceptibility. https://twitter.com/VincentRK/status/1276159410264576000
A beautiful thread illustrating this in U.K. https://twitter.com/stevebrown2856/status/1280067312071122945
