Early obesity is characterized by beta cell hypertrophy. Understanding how hyperinsulinemia, IR, glucagon & insulin/glucagon ratio contributes to nutrient homeostasis in obesity is key to understanding metabolic syndrome. Our focus should be on this rather than drugs @meganjramos

Beta cell hypertrophy is a feature of early obesity, IR & early type II diabetes. The glucagon levels vary depending on the stage of beta cell dysfunction & degree of IR. The low carb proponents are in a unique position of understand & explore this paradigm @holmanm @OZmandia