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Results of a bottom-up interdisciplinary approach - COVID19 International analysis checklist -
annex:
(ACE) polymorphisms hypotheses - v5.0
Thank you to all contributors
annex:
(ACE) polymorphisms hypotheses - v5.0
Thank you to all contributors
Links of this annex:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102561/
http://tinyurl.com/y88fh5hn
https://doi.org/10.1101/2020.04.23.057042
https://doi.org/10.1101/2020.05.27.20114843
https://doi.org/10.1177/2047487320931305 https://doi.org/10.1101/2020.06.18.20135152
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102561/
http://tinyurl.com/y88fh5hn
https://doi.org/10.1101/2020.04.23.057042
https://doi.org/10.1101/2020.05.27.20114843
https://doi.org/10.1177/2047487320931305 https://doi.org/10.1101/2020.06.18.20135152
For information - blood/loci: "In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EA individuals, we identified 5552 trait-variant associations, including 71 novel loci (not found in EA populations)" https://twitter.com/GLettre/status/1219075403987456011?s=19
"Haplotypesmarked as carriers contain the minor allele of rs10490770, which is in perfect LD in Eurasianpopulations with the leading risk polymorphisms. All carriers fall in a clade with the Neandertalgenomes."
(paper found thanks to @GeneticLifehack) https://twitter.com/GeneticLifehack/status/1279408919601991680
(paper found thanks to @GeneticLifehack) https://twitter.com/GeneticLifehack/status/1279408919601991680
"Conclusions: Adverse outcome of COVID19 was associated with male gender, hypertension, hypercholesterolemia and the ACE1 genotype. The ACE1-indel was a significant risk factor for severe COVID19, but the effect was dependent on the hypertensive status." https://www.medrxiv.org/content/10.1101/2020.06.11.20128033v1
"The technology required, like being able to peer inside a single cell & see what proteins it’s making compared to its neighbours, has only evolved in the last few years. “(...) & that we’ll get there for this disease probably within the next decade.”" https://www.wired.co.uk/article/coronavirus-ace2
Some nuance / alternative prism from @nanogenomic
(SNP = Single-nucleotide polymorphism - some background info : https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism) https://twitter.com/nanogenomic/status/1283688361979293696
(SNP = Single-nucleotide polymorphism - some background info : https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism) https://twitter.com/nanogenomic/status/1283688361979293696
As this thread includes the opinion of @nanogenomic - see this visual representation of SARS-COV-2 spike protein bound to ACE2 (red) with glycosylation (sugar modifications) on both proteins (video): https://twitter.com/nanogenomic/status/1278478845675360256
