Meat is high in Glycosaminoglycans
(central to coronavirus& #39;s ability to attach to host cells)
Beef, pork poultry, seafood are rich in heparan sulfate (glycosaminoglycans), highly charged anchors for SARSCoV2
Meat surfaces critical factors for transmission
https://www.biorxiv.org/content/10.1101/2020.02.29.971093v1">https://www.biorxiv.org/content/1... https://twitter.com/BillyBostickson/status/1276246555012370432">https://twitter.com/BillyBost...
(central to coronavirus& #39;s ability to attach to host cells)
Beef, pork poultry, seafood are rich in heparan sulfate (glycosaminoglycans), highly charged anchors for SARSCoV2
Meat surfaces critical factors for transmission
https://www.biorxiv.org/content/10.1101/2020.02.29.971093v1">https://www.biorxiv.org/content/1... https://twitter.com/BillyBostickson/status/1276246555012370432">https://twitter.com/BillyBost...
1/5 Science behind that tweet just in case anyone thinks I speak without awareness ;)
Glycosaminoglycans from fresh water fish processing discard - Isolation, structural characterization, and osteogenic activity
https://www.researchgate.net/publication/338173546_Glycosaminoglycans_from_fresh_water_fish_processing_discard_-_Isolation_structural_characterization_and_osteogenic_activity
SALMON">https://www.researchgate.net/publicati... MOUTHS
Glycosaminoglycans from fresh water fish processing discard - Isolation, structural characterization, and osteogenic activity
https://www.researchgate.net/publication/338173546_Glycosaminoglycans_from_fresh_water_fish_processing_discard_-_Isolation_structural_characterization_and_osteogenic_activity
SALMON">https://www.researchgate.net/publicati... MOUTHS
2/5 Salmon Mouths 2
Characterization of Glycosaminoglycans in Gaping and Intact Connective Tissues of Farmed Atlantic Salmon (Salmo salar) Fillets by Mass Spectrometry https://pubs.acs.org/doi/10.1021/acsomega.9b01136">https://pubs.acs.org/doi/10.10...
Characterization of Glycosaminoglycans in Gaping and Intact Connective Tissues of Farmed Atlantic Salmon (Salmo salar) Fillets by Mass Spectrometry https://pubs.acs.org/doi/10.1021/acsomega.9b01136">https://pubs.acs.org/doi/10.10...
3/5 Why does SARS-COV-2 like meat & seafood?
Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry
https://www.biorxiv.org/content/10.1101/2020.04.14.041459v1.full
Glycosaminoglycans">https://www.biorxiv.org/content/1... and infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975577/">https://www.ncbi.nlm.nih.gov/pmc/artic...
Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry
https://www.biorxiv.org/content/10.1101/2020.04.14.041459v1.full
Glycosaminoglycans">https://www.biorxiv.org/content/1... and infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975577/">https://www.ncbi.nlm.nih.gov/pmc/artic...
4/5 Glycosaminoglycans
Role of in Infectious Disease
(same authors as above)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624626/
Glycosaminoglycans">https://www.ncbi.nlm.nih.gov/pmc/artic... in Infectious Disease
https://pubmed.ncbi.nlm.nih.gov/23551941/
Murine">https://pubmed.ncbi.nlm.nih.gov/23551941/... Coronavirus with an Extended Host Range Uses Heparan Sulfate as an Entry Receptor
https://jvi.asm.org/content/79/22/14451">https://jvi.asm.org/content/7...
Role of in Infectious Disease
(same authors as above)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624626/
Glycosaminoglycans">https://www.ncbi.nlm.nih.gov/pmc/artic... in Infectious Disease
https://pubmed.ncbi.nlm.nih.gov/23551941/
Murine">https://pubmed.ncbi.nlm.nih.gov/23551941/... Coronavirus with an Extended Host Range Uses Heparan Sulfate as an Entry Receptor
https://jvi.asm.org/content/79/22/14451">https://jvi.asm.org/content/7...
5/5 Meatpacking plants & Heparan
Meatpacking plants & COVID-19 outbreaks
https://healthtranslationsa.org.au/wp-content/uploads/2020/05/Meat-Packing-Clusters-COVID-19-Evidence-Update_12-May-2020.pdf
Heparan">https://healthtranslationsa.org.au/wp-conten... Sulfate Proteoglycans and Viral Attachment:
https://www.mdpi.com/1999-4915/11/7/596/htm
Severity">https://www.mdpi.com/1999-4915... of COVID-19 linked to heparanase activity and heparan sulfate levels
https://www.news-medical.net/news/20200616/Severity-of-COVID-19-linked-to-heparanase-activity-and-heparan-sulfate-levels.aspx">https://www.news-medical.net/news/2020...
Meatpacking plants & COVID-19 outbreaks
https://healthtranslationsa.org.au/wp-content/uploads/2020/05/Meat-Packing-Clusters-COVID-19-Evidence-Update_12-May-2020.pdf
Heparan">https://healthtranslationsa.org.au/wp-conten... Sulfate Proteoglycans and Viral Attachment:
https://www.mdpi.com/1999-4915/11/7/596/htm
Severity">https://www.mdpi.com/1999-4915... of COVID-19 linked to heparanase activity and heparan sulfate levels
https://www.news-medical.net/news/20200616/Severity-of-COVID-19-linked-to-heparanase-activity-and-heparan-sulfate-levels.aspx">https://www.news-medical.net/news/2020...
6/
"Evidence is mounting that SARS-CoV-2 uses heparan sulfates during initial attachment to hosts cells & this interaction increases affinity for critical receptor, ACE2.
Spike protein has high affinity for heparin, particularly unfractionated heparin" https://www.azolifesciences.com/news/20200609/Investigating-the-role-of-heparins-in-combating-Covid-19-infection.aspx">https://www.azolifesciences.com/news/2020...
"Evidence is mounting that SARS-CoV-2 uses heparan sulfates during initial attachment to hosts cells & this interaction increases affinity for critical receptor, ACE2.
Spike protein has high affinity for heparin, particularly unfractionated heparin" https://www.azolifesciences.com/news/20200609/Investigating-the-role-of-heparins-in-combating-Covid-19-infection.aspx">https://www.azolifesciences.com/news/2020...
7/ Glycan Binding
Binding of the SARS-CoV-2 Spike Protein to Glycans
https://www.biorxiv.org/content/10.1101/2020.05.17.100537v1.full.pdf
The">https://www.biorxiv.org/content/1... 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
https://www.biorxiv.org/content/10.1101/2020.02.29.971093v2">https://www.biorxiv.org/content/1...
Binding of the SARS-CoV-2 Spike Protein to Glycans
https://www.biorxiv.org/content/10.1101/2020.05.17.100537v1.full.pdf
The">https://www.biorxiv.org/content/1... 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
https://www.biorxiv.org/content/10.1101/2020.02.29.971093v2">https://www.biorxiv.org/content/1...
8/ Sacrificed Seafood Workers Left in the Dark?
https://www.mercurynews.com/2020/05/26/coronavirus-outbreak-hits-morgan-hill-fish-packing-plant/
https://www.mercurynews.com/2020/05/2... href=" https://www.bizjournals.com/sanjose/news/2020/05/26/covid-outbreak-lusamerica-morgan-hill.html
https://www.bizjournals.com/sanjose/n... href=" https://www.seafoodsource.com/news/supply-trade/pacific-seafood-suspends-operations-at-five-locations-due-to-covid-19-outbreak
https://www.seafoodsource.com/news/supp... href=" https://www.kpbs.org/news/2020/jun/05/covid-19-outbreak-in-pacific-northwest-seafood/
https://www.kpbs.org/news/2020... href=" https://ohsonline.com/articles/2020/06/10/seafood-market-facing-covid19-outbreaks-too.aspx
https://ohsonline.com/articles/... href=" https://www.alaskapublic.org/2020/06/09/a-seattle-fishing-company-has-more-than-100-covid-19-cases-on-its-ships-theyre-heading-to-alaska-this-summer/
https://www.alaskapublic.org/2020/06/0... href=" https://www.registerguard.com/news/20200609/newport-seafood-plant-has-124-covid-19-cases-second-largest-outbreak-in-oregon
https://www.registerguard.com/news/2020... href=" https://www.npr.org/sections/coronavirus-live-updates/2020/06/05/870312092/pacific-northwest-seafood-industry-faces-covid-19-outbreak-as-season-ramps-up
https://www.npr.org/sections/... href=" https://www.undercurrentnews.com/2020/01/29/coronavirus-outbreak-chile-norway-sellers-redirect-salmon-to-us-as-china-orders-cancelled/">https://www.undercurrentnews.com/2020/01/2...
https://www.mercurynews.com/2020/05/26/coronavirus-outbreak-hits-morgan-hill-fish-packing-plant/
https://www.mercurynews.com/2020/05/2... href=" https://www.bizjournals.com/sanjose/news/2020/05/26/covid-outbreak-lusamerica-morgan-hill.html
https://www.bizjournals.com/sanjose/n... href=" https://www.seafoodsource.com/news/supply-trade/pacific-seafood-suspends-operations-at-five-locations-due-to-covid-19-outbreak
https://www.seafoodsource.com/news/supp... href=" https://www.kpbs.org/news/2020/jun/05/covid-19-outbreak-in-pacific-northwest-seafood/
https://www.kpbs.org/news/2020... href=" https://ohsonline.com/articles/2020/06/10/seafood-market-facing-covid19-outbreaks-too.aspx
https://ohsonline.com/articles/... href=" https://www.alaskapublic.org/2020/06/09/a-seattle-fishing-company-has-more-than-100-covid-19-cases-on-its-ships-theyre-heading-to-alaska-this-summer/
https://www.alaskapublic.org/2020/06/0... href=" https://www.registerguard.com/news/20200609/newport-seafood-plant-has-124-covid-19-cases-second-largest-outbreak-in-oregon
https://www.registerguard.com/news/2020... href=" https://www.npr.org/sections/coronavirus-live-updates/2020/06/05/870312092/pacific-northwest-seafood-industry-faces-covid-19-outbreak-as-season-ramps-up
https://www.npr.org/sections/... href=" https://www.undercurrentnews.com/2020/01/29/coronavirus-outbreak-chile-norway-sellers-redirect-salmon-to-us-as-china-orders-cancelled/">https://www.undercurrentnews.com/2020/01/2...
9/ Not even one word about Heparan Binding or Glycosaminoglycans by the WHO, FDA or the CDC!
Coronavirus Disease 2019 (COVID-19)
Interim Guidance from CDC & OSHA.
Developed in consultation with Food & Drug Administration (FDA) for Seafood Workers
https://www.cdc.gov/coronavirus/2019-ncov/community/guidance-seafood-processing.html">https://www.cdc.gov/coronavir...
Coronavirus Disease 2019 (COVID-19)
Interim Guidance from CDC & OSHA.
Developed in consultation with Food & Drug Administration (FDA) for Seafood Workers
https://www.cdc.gov/coronavirus/2019-ncov/community/guidance-seafood-processing.html">https://www.cdc.gov/coronavir...
9/ How about Meat Workers?
Any useful advice from CDC or Mass Media or "Experts"?
115 Meat Plants
https://www.packagingstrategies.com/articles/95498-cdc-reports-115-meat-or-poultry-processing-facilities-are-contending-with-covid-19-outbreak
Revealed:">https://www.packagingstrategies.com/articles/... why meat processing plants are the ideal incubator of the coronavirus
https://www.telegraph.co.uk/global-health/science-and-disease/revealed-meat-processing-plants-ideal-incubator-coronavirus/
Not">https://www.telegraph.co.uk/global-he... a bloody chance as long as meat is on the table!
Any useful advice from CDC or Mass Media or "Experts"?
115 Meat Plants
https://www.packagingstrategies.com/articles/95498-cdc-reports-115-meat-or-poultry-processing-facilities-are-contending-with-covid-19-outbreak
Revealed:">https://www.packagingstrategies.com/articles/... why meat processing plants are the ideal incubator of the coronavirus
https://www.telegraph.co.uk/global-health/science-and-disease/revealed-meat-processing-plants-ideal-incubator-coronavirus/
Not">https://www.telegraph.co.uk/global-he... a bloody chance as long as meat is on the table!
10/ So-Called Evidence Based Science is based on Ignorance
What explains high rate of SARS-CoV-2 transmission in meat & poultry facilities?
https://www.cebm.net/covid-19/what-explains-the-high-rate-of-sars-cov-2-transmission-in-meat-and-poultry-facilities-2/">https://www.cebm.net/covid-19/...
What explains high rate of SARS-CoV-2 transmission in meat & poultry facilities?
https://www.cebm.net/covid-19/what-explains-the-high-rate-of-sars-cov-2-transmission-in-meat-and-poultry-facilities-2/">https://www.cebm.net/covid-19/...
11/ Murdering Meat Workers with
Ignorance & Naive Narratives
Meanwhile the BBC and Public Heath England say:
"There is no evidence that the meat products themselves could be a source of Covid-19 infection at the plants" https://www.bbc.com/news/53137613 ">https://www.bbc.com/news/5313...
Ignorance & Naive Narratives
Meanwhile the BBC and Public Heath England say:
"There is no evidence that the meat products themselves could be a source of Covid-19 infection at the plants" https://www.bbc.com/news/53137613 ">https://www.bbc.com/news/5313...
12/ Meat & Ignorance Exposed
https://www.wired.com/story/why-meatpacking-plants-have-become-covid-19-hot-spots/
https://www.wired.com/story/why... href=" https://www.infomigrants.net/en/post/24857/germany-s-meat-industry-under-fire-after-covid-19-outbreaks
https://www.infomigrants.net/en/post/2... href=" https://www.dw.com/en/coronavirus-fourth-large-outbreak-at-german-slaughterhouse/a-53476800
https://www.dw.com/en/corona... href=" https://www.theguardian.com/world/2020/may/15/us-coronavirus-meat-packing-plants-food
https://www.theguardian.com/world/202... href=" https://www.bbc.com/news/world-us-canada-52311877
"Expert"">https://www.bbc.com/news/worl... advice
https://www.cdc.gov/mmwr/volumes/69/wr/mm6918e3.htm
"Expert"">https://www.cdc.gov/mmwr/volu... comments about meat processing plants & COVID-19 outbreaks
https://www.sciencemediacentre.org/expert-comments-about-meat-processing-plants-and-slaughterhouses-and-covid-19-outbreaks/">https://www.sciencemediacentre.org/expert-co...
https://www.wired.com/story/why-meatpacking-plants-have-become-covid-19-hot-spots/
https://www.wired.com/story/why... href=" https://www.infomigrants.net/en/post/24857/germany-s-meat-industry-under-fire-after-covid-19-outbreaks
https://www.infomigrants.net/en/post/2... href=" https://www.dw.com/en/coronavirus-fourth-large-outbreak-at-german-slaughterhouse/a-53476800
https://www.dw.com/en/corona... href=" https://www.theguardian.com/world/2020/may/15/us-coronavirus-meat-packing-plants-food
https://www.theguardian.com/world/202... href=" https://www.bbc.com/news/world-us-canada-52311877
"Expert"">https://www.bbc.com/news/worl... advice
https://www.cdc.gov/mmwr/volumes/69/wr/mm6918e3.htm
"Expert"">https://www.cdc.gov/mmwr/volu... comments about meat processing plants & COVID-19 outbreaks
https://www.sciencemediacentre.org/expert-comments-about-meat-processing-plants-and-slaughterhouses-and-covid-19-outbreaks/">https://www.sciencemediacentre.org/expert-co...
13/ Pigs? is it safe to eat Meat?
New research suggests industrial livestock, not wet markets, might be origin of Covid-19
https://www.grain.org/en/article/6437-new-research-suggests-industrial-livestock-not-wet-markets-might-be-origin-of-covid-19
Is">https://www.grain.org/en/articl... Eating Meat From Meatpacking Plants With Covid-19 Coronavirus Outbreaks Safe?
#1360b9e47089">https://www.forbes.com/sites/victoriaforster/2020/06/21/is-eating-meat-from-meatpacking-plants-with-covid-19-coronavirus-outbreaks-safe/ #1360b9e47089
Food">https://www.forbes.com/sites/vic... 4 Thought & Gd Night!
New research suggests industrial livestock, not wet markets, might be origin of Covid-19
https://www.grain.org/en/article/6437-new-research-suggests-industrial-livestock-not-wet-markets-might-be-origin-of-covid-19
Is">https://www.grain.org/en/articl... Eating Meat From Meatpacking Plants With Covid-19 Coronavirus Outbreaks Safe?
#1360b9e47089">https://www.forbes.com/sites/victoriaforster/2020/06/21/is-eating-meat-from-meatpacking-plants-with-covid-19-coronavirus-outbreaks-safe/ #1360b9e47089
Food">https://www.forbes.com/sites/vic... 4 Thought & Gd Night!
14/ via @liljurist
Presence of protein (as well as temp & humidity) seems to extend viability of virons to survive for longer periods, which over time, will lead to an increase in viral load as more virus is shed, but not neutralized by the environment. https://oie.int/doc/ged/d8191.pdf">https://oie.int/doc/ged/d...
Presence of protein (as well as temp & humidity) seems to extend viability of virons to survive for longer periods, which over time, will lead to an increase in viral load as more virus is shed, but not neutralized by the environment. https://oie.int/doc/ged/d8191.pdf">https://oie.int/doc/ged/d...
15/ Corpses
via @liljurist
The virus remains active for âhours if not daysâ in the recently deceased, at least one known infection so far from handling post mortem remains. https://www.miamiherald.com/news/coronavirus/article242085146.html">https://www.miamiherald.com/news/coro...
via @liljurist
The virus remains active for âhours if not daysâ in the recently deceased, at least one known infection so far from handling post mortem remains. https://www.miamiherald.com/news/coronavirus/article242085146.html">https://www.miamiherald.com/news/coro...
16/ Proteins via @liljurist
âSARS-CoV-2 infectivity remarkably preserved in presence of proteins, regardless of surfaceâ
FC strengthens binding to saccharides but increased transmissibility of CoV2 at low temp, high humidity, protein rich environments, warrants further study.
âSARS-CoV-2 infectivity remarkably preserved in presence of proteins, regardless of surfaceâ
FC strengthens binding to saccharides but increased transmissibility of CoV2 at low temp, high humidity, protein rich environments, warrants further study.
17/ Raw Meat. Protein and Fomites
@flavinkins notes:
"In raw meat kept sterile by modern packing environments"
while @liljurist reminds us:
Prolonged Infectivity of SARS-CoV-2 in Fomites â Presence of Protein increases period of bioavailability. https://pubmed.ncbi.nlm.nih.gov/32579874/ ">https://pubmed.ncbi.nlm.nih.gov/32579874/...
@flavinkins notes:
"In raw meat kept sterile by modern packing environments"
while @liljurist reminds us:
Prolonged Infectivity of SARS-CoV-2 in Fomites â Presence of Protein increases period of bioavailability. https://pubmed.ncbi.nlm.nih.gov/32579874/ ">https://pubmed.ncbi.nlm.nih.gov/32579874/...
18/ Sticky SARS-COV-2?
@flavinkins conludes:
"Since Heparan sulfate binding motif XBBXBX is same as minimum furin cleavage site motif XRRXRX, if you engineer it in, it will stick to everything that touches water, fish, meat, etc, no matter if it will infect the animal or not"
@flavinkins conludes:
"Since Heparan sulfate binding motif XBBXBX is same as minimum furin cleavage site motif XRRXRX, if you engineer it in, it will stick to everything that touches water, fish, meat, etc, no matter if it will infect the animal or not"
19/ A possible cure?
via @flavinkins
Could Heparan sulfate be injected to cure SARS-COV-2?
It will clump with the virus & stop attachment
It will cause them to clump together & be essentially neutralized.
This explains why injected Heparin is so effective for patients.
via @flavinkins
Could Heparan sulfate be injected to cure SARS-COV-2?
It will clump with the virus & stop attachment
It will cause them to clump together & be essentially neutralized.
This explains why injected Heparin is so effective for patients.
20/ More on Heparin via @TrueOriginCOVID
"Association between treatment with heparin & survival in patients with Covid-19"
study investigates association between treatment with heparin & mortality in patients admitted with Covid-19 https://www.springermedizin.de/covid-19/the-association-between-treatment-with-heparin-and-survival-in-p/18036042">https://www.springermedizin.de/covid-19/...
"Association between treatment with heparin & survival in patients with Covid-19"
study investigates association between treatment with heparin & mortality in patients admitted with Covid-19 https://www.springermedizin.de/covid-19/the-association-between-treatment-with-heparin-and-survival-in-p/18036042">https://www.springermedizin.de/covid-19/...
unroll @threadreaderapp