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Its out! Our @ActinoBase review of actinomycete research in 2019! Written by an all-ECR team of @Sam_Prudence @emyaddington @Laia_Castano @DavidRcoMark @LinaPintorE @alisia_russell and myself. Read it here for free on @MicrobioSoc ! https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000944">https://www.microbiologyresearch.org/content/j...
In it we cover 10 publications from last year and I& #39;ll go through them quickly in this thread, sorry if I miss any twitter handles! We really hope you enjoy our review, its a slightly different format to most but when you want to read more i& #39;ve linked to the papers in the thread!
The first is the work by @K_Gallag et al. (including @MatthewJBush and @nholmes1504) on c-di-GMP& #39;s fascinating role in regulating streptomycete development which you can read here: https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30835-4">https://www.cell.com/molecular...
Then we move on to the work by Emma Gehrke et al. (including @StephEJones30 and @JNodwell) investigating the remarkable nucleoid-associated protein Lsr2, which you can read here: https://elifesciences.org/articles/47691 ">https://elifesciences.org/articles/...
Up next is the discovery of the salinipeptins: unusual D-amino acid-containing RiPPs from a Great Salt Lake streptomycete by Zhuo Shang et al. available here: https://pubs.acs.org/doi/10.1021/acschembio.8b01058">https://pubs.acs.org/doi/10.10...
Then the great work by @Becca_McHugh et al. (including @PaulHoskisson) on discovering new uses for old drugs, in this case revealing the anti-virulence mechanism of aurodox! Read here: https://iai.asm.org/content/87/2/e00595-18
Watch">https://iai.asm.org/content/8... Becca& #39;s brilliant @ActinoBase e-Seminar https://www.youtube.com/watch?v=2swuBetcmSI">https://www.youtube.com/watch...
Watch">https://iai.asm.org/content/8... Becca& #39;s brilliant @ActinoBase e-Seminar https://www.youtube.com/watch?v=2swuBetcmSI">https://www.youtube.com/watch...
Last specialised metabolites paper is looking into the history of glycopeptide antibiotic biosynthesis and resistance by Nicholas Waglechner et al. ( @gerryiidr) which you can find here: https://www.nature.com/articles/s41564-019-0531-5">https://www.nature.com/articles/...
Next is looking at ancient polar actinomycetes and their antibiotic potential by Natalie Millán-Aguiñaga et al. (including @SylviaSoldatou , @Munnj90 and @kate_duncan available here: https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000845">https://www.microbiologyresearch.org/content/j...
Before we then look at the amazing local adaptation of leaf cutter ant Pseudonocardia symbionts and Escovopsis pathogens and the implications of geographic mosaic theory of coevolution by Eric Caldera et al. (including @wildtypeMC) available here: https://pubmed.ncbi.nlm.nih.gov/31676475/ ">https://pubmed.ncbi.nlm.nih.gov/31676475/...
Last symbiont paper is about a curious association between streptomycetes, strawberry plants and pollinating bees by Da-Ran Kim el al. which you can read here: https://www.nature.com/articles/s41467-019-12785-3">https://www.nature.com/articles/...
Finally we move onto advances in methodology & technology and first look at a great new update to the invaluable antiSMASH with its 5.0 update by @kaiblin et al. (including @NadineZiemert, @marnixmedema & @tilmweber ) available here: https://academic.oup.com/nar/article/47/W1/W81/5481154">https://academic.oup.com/nar/artic...
Last but certainly not least is the new CRISPR-BEST base editing system for actinomycete genome engineering by @TongYaojun et al. (including @tilmweber and @mbelmbel99) which can be found here: https://www.pnas.org/content/pnas/116/41/20366.full.pdf">https://www.pnas.org/content/p...
You can also listen to @TongYaojun& #39;s brilliant @ActinoBase e-Seminar on CRISPR-BEST here: https://www.youtube.com/watch?v=cecBKLoonu4">https://www.youtube.com/watch... !
