Just out in @JAMADerm, in one of the largest and most comprehensive dietary cohorts (Nutri-Net Sante cohort), milk (aOR 1.12), sugary beverage (aOR 1.18), and fatty & sugary product consumption (aOR 1.53) were each associated with patient reported current acne. Some thoughtshttps://abs.twimg.com/emoji/v2/... draggable="false" alt="⬇️" title="Pfeil nach unten" aria-label="Emoji: Pfeil nach unten">1/ https://twitter.com/JAMADerm/status/1270747563533180928">https://twitter.com/JAMADerm/...

These findings are largely in line with prior studies suggesting that milk consumption and high glycemic load diet are associated with acne. Both can lead to increased levels of IGF-1, which is involved in the pathophysiology of acne. 2/

In addition, 20% of the protein in milk is composed of whey, which has been associated with the development of acne in several case reports among men taking whey protein supplements. 3/ https://pubmed.ncbi.nlm.nih.gov/22988649 ">https://pubmed.ncbi.nlm.nih.gov/22988649&...

However, it is important to keep in mind that this study design cannot assess causality and the effect sizes were generally small; as a result, the influence of diet on acne may not be clinically meaningful for many patients 4/

In addition, nutritional epidemiology research is challenging with many potential confounders, and it is often difficulty to replicate findings from these studies in randomized trials. Therefore, we should interpret the results of this study cautiously. 5/ https://pubmed.ncbi.nlm.nih.gov/30746584 ">https://pubmed.ncbi.nlm.nih.gov/30746584&...

Fortunately, two small RCTs have shown that low glycemic load diet can improve acne. Given the potential overall health benefits of a low glycemic load diet, it is a reasonable recommendation for those looking for dietary modifications for their acne. 6/ https://pubmed.ncbi.nlm.nih.gov/17616769 ">https://pubmed.ncbi.nlm.nih.gov/17616769&...

Overall, this study is a nice starting place. Going forward, we need randomized trials to evaluate whether dietary interventions (such as https://abs.twimg.com/emoji/v2/... draggable="false" alt="⬇️" title="Pfeil nach unten" aria-label="Emoji: Pfeil nach unten">dairy/sugar) can improve or prevent acne and how the effect size of such interventions compare with other standard treatment modalities. 7/

For more information, check out the associated editorial on diet and acne in @JAMADerm 8/end https://jamanetwork.com/journals/jamadermatology/article-abstract/2767070">https://jamanetwork.com/journals/...