From @TheLancet #hydroxychloroquine author

"The real question here is, with data like this (quality and scale), do we even need randomized controlled trial?"

Yes https://docs.google.com/document/d/1M01bvgS2ret1IuPaEV70XSWnEwizsHLUM-_GpQSEIUA/edit?usp=sharing https://twitter.com/boback/status/1266808172460666880

h/t @boback full video

This video hit my nerves so hard that I decide to open my letter. Take home message: with data like this scale & quality, discrepancy and bias still exist (and may dominate). Don't want to be greedy to push reanalysis, but @TheLancet, Please add "RCT is still needed" to abstract!

Concerns on the data source behind this paper https://twitter.com/ellis2013nz/status/1266739627701854208

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524 same database, same analysis by same team have been used to propose ivermectin for COVID-19. Right now 18 trials have been registered in clinicaltrials. Concerning.

https://twitter.com/reverendofdoubt/status/1266902969045463041?s=21 excellent thread about pros and cons of EHR dataset. https://twitter.com/reverendofdoubt/status/1266902969045463041