We now show the actual motion through measurement of the dynamics of turnover in mouse stem cells determining rates of de novo methylation and active and passive demethylation.
Turns out that methylation is not as static as you might think as even highly methylated cytosines can be under rapid cycles of de- and remethylation.
Most of this action is around enhancers and active genes, where transcription factor activity causes active and passive demethylation and DNA methyltransferases try to make up for it.
Congrats to Paul, Dimos and @angifeldmann and all others involved for pushing this through and solving the ample experimental and computational challenges along the way.
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